Isolation, purification and identification of antioxidants from Lepidium latifolium extracts
文献类型：期刊论文
| 作者 | Yuan Xiang1,2; Wang Haixia1; Mei Lijuan1; Tao Yanduo1 |
| 刊名 | MEDICINAL CHEMISTRY RESEARCH
 |
| 出版日期 | 2018 |
| 卷号 | 27期号:1页码:37-45 |
| 关键词 | Lepidium Latifolium Antioxidant Activity Bioassay-guided Column Chromatography Structures |
| DOI | 10.1007/s00044-017-2042-3 |
| 英文摘要 | Antioxidant potencies of an ethanolic extract and its components from Lepidium latifolium were investigated. In this study, we found that the ethyl acetate soluble fraction of L. latifolium was a rich source of antioxidant, resulting from its high total phenolic content. To determine the antioxidant components of the ethyl acetate fraction, a bioassay-guided fractionation approach using 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate), and ferric reducing antioxidant power assays were conducted. Nine compounds were isolated and their structures were identified by MS and NMR spectral data and comparison to reported data. They are Quercetin-3-O-beta-d-sophoroside-7-O-alpha-l-rhamnoside (1), Apetalumoside B6 (2), Kaempferol-3-O-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (3), Kaempferol-7-O-alpha-l-rhamnopyranoside (4), Kaempferol-3-O-beta-D-glucopyranoside-7-O-alpha-l-rhamnopyranoside (5), Kaempferol-3-O-(2-O-feruloyl-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside)-7-O-glucopyranoside (6), Kaempferol-3-O-beta-D-sophoroside-7-O-alpha-l-rhamnoside (7), Kaempferol-3-O-robinoside-7-O-(2aEuro(3)aEuro(3)-(E)-feruloyl)-sophoroside (8), Quercetin-3-O-(2,6-di-O-beta-D-glucopyranosyl)-beta-D-glucopyranoside-7-O-alpha-l-rhamnopyranoside (9), compounds 1, 2, 4, and 8 had potent free radical scavenging activity. The IC50 values of these compounds were 9.8-12.3 and 7.4-31.4 mu g/mL in DPPH and ABTS assays, respectively. The results indicate that L. latifolium is a potential natural source of antioxidants to treat several diseases related to oxidant by-products of human metabolism. |
| 语种 | 英语 |
| WOS记录号 | WOS:000419972400004 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13299]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan Xiang,Wang Haixia,Mei Lijuan,et al. Isolation, purification and identification of antioxidants from Lepidium latifolium extracts[J]. MEDICINAL CHEMISTRY RESEARCH,2018,27(1):37-45. |
| APA | Yuan Xiang,Wang Haixia,Mei Lijuan,&Tao Yanduo.(2018).Isolation, purification and identification of antioxidants from Lepidium latifolium extracts.MEDICINAL CHEMISTRY RESEARCH,27(1),37-45. |
| MLA | Yuan Xiang,et al."Isolation, purification and identification of antioxidants from Lepidium latifolium extracts".MEDICINAL CHEMISTRY RESEARCH 27.1(2018):37-45. |
入库方式： OAI收割
来源：西北高原生物研究所
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