The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep
文献类型：期刊论文
| 作者 | Zhang, Rui-Na1; Pang, Bo1; Xu, Shang-Rong2; Wan, Peng-Cheng3; Guo, Song-Chang1; Ji, Han-Zhong4; Jia, Gong-Xue1; Hu, Lin-Yong1 ; Zhao, Xin-Quan1; Yang, Qi-En1,5
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| 刊名 | THERIOGENOLOGY
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 107页码:85-94 |
| 关键词 | Sheep Ovary Cxcl12 Cxcr4 Oocyte In Vitro Maturation |
| DOI | 10.1016/j.theriogenology.2017.10.039 |
| 英文摘要 | Gonadotropins and growth factors synergistically regulate folliculogenesis and oocyte development. C-XC motif chemokine 12 (CXCL12) and its receptor CXCR4 are expressed in ovaries of sheep, cattle and other species, however, roles of this multifunctional signal axis in oocyte maturation are not defined. Using sheep as a model, we examined the expression patterns and functions of the CXCL12-CXCR4 axis during oocyte maturation. CXCL12 and CXCR4 mRNA and protein were present in oocytes and granulosa cells. Relative abundance of CXCR4 transcript was controlled by epidermal growth factor (EGF). Transient inhibition of CXCR4 suppressed oocyte nuclear maturation while supplementing recombination CXCL12 significantly increased percent of oocyte undergone metaphase I phase. Inhibition of CXCR4 function decreased cumulus expansion growth rate. Furthermore, granulosa cell migration was impaired and expression of hyaluronan synthase 2 (HAS2) and hyaluronan binding protein tumor necrosis factor alpha-induced protein 6 (TNFAIP6) were downregulated by CXCR4 inhibition. These findings revealed a novel role of the CXCL12-CXCR4 signaling in oocyte development in sheep. (C) 2017 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000422892800012 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13311]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Evolut & Adaptat Plateau Biota, Xining 810008, Qinghai, Peoples R China 2.Qinghai Univ, Qinghai Acad Anim Sci & Vet Med, Xining 810016, Qinghai, Peoples R China 3.Xinjiang Acad Agr & Reclamat Sci, Anim Husb & Vet Inst, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832003, Peoples R China 4.Haibei Inst Anim Husb & Vet Sci, Haibei 810299, Tibetan Autonom, Peoples R China 5.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Ecol Genom, Xining 810008, Qinghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Rui-Na,Pang, Bo,Xu, Shang-Rong,et al. The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep[J]. THERIOGENOLOGY,2018,107:85-94. |
| APA | Zhang, Rui-Na.,Pang, Bo.,Xu, Shang-Rong.,Wan, Peng-Cheng.,Guo, Song-Chang.,...&Yang, Qi-En.(2018).The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep.THERIOGENOLOGY,107,85-94. |
| MLA | Zhang, Rui-Na,et al."The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep".THERIOGENOLOGY 107(2018):85-94. |
入库方式： OAI收割
来源：西北高原生物研究所
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