Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro
文献类型：期刊论文
| 作者 | Luan, Guangxiang1,2,4; Wang, Yuwei1,2,4; Wang, Zhenhua3; Zhou, Wenna1,2,4; Hu, Na2,4; Li, Gang3; Wang, Honglun2,4 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2018-03-28 |
| 卷号 | 66期号:12页码:3169-3178 |
| 关键词 | Fenugreek Seeds Flavonoid Glycosides Isoorientin Insulin Resistance 3t3-l1 Adipocytes Mitochondrial Function |
| DOI | 10.1021/acs.jafc.8b00179 |
| 英文摘要 | Fenugreek is a well known annual herb widely used in both medicine and food. Four flavonoid glycosides have been separated from fenugreek seeds in our previous study. In this study, the effects of the four flavonoid glycosides on regulating glycolipid metabolism and improving mitochondrial function were investigated. Isoorientin showed a very significant activity among these flavonoid glycosides. First, isoorientin decreased the accumulation of lipid droplets in 3T3-L1 preadipocytes by reducing the expression of adipokines including PPARy, C/EBP alpha, and FAS. Second, isoorientin restored insulin-stimulated glucose uptake in dexamethasone-induced insulin-resistant 3T3-L1 adipocytes by reactivating Akt and AMPK. Finally, isoorientin improved mitochondrial dysfunction induced by dexamethasone in 3T3-L1 adipocytes. Isoorientin also reversed dexamethasone-induced decrease in mitochondrial membrane potential (MMP) and intracellular ATP production, reduced accumulation of intracellular reactive oxygen species (ROS), and protected mitochondrial DNA (mtDNA) from oxidative damage. At the same time, mitochondrial biogenesis is promoted. Therefore, isoorientin may be an attractive candidate as a glucose-lowering and insulin-resistance-improving agent for the treatment of diabetes. |
| 语种 | 英语 |
| WOS记录号 | WOS:000428972400016 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13351]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China 3.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China 4.Key Lab Tibetan Med Res Qinghai Prov, 251 Ningda Rd, Xining, Qinghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luan, Guangxiang,Wang, Yuwei,Wang, Zhenhua,et al. Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(12):3169-3178. |
| APA | Luan, Guangxiang.,Wang, Yuwei.,Wang, Zhenhua.,Zhou, Wenna.,Hu, Na.,...&Wang, Honglun.(2018).Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(12),3169-3178. |
| MLA | Luan, Guangxiang,et al."Flavonoid Glycosides from Fenugreek Seeds Regulate Glycolipid Metabolism by Improving Mitochondria! Function in 3T3-L1 Adipocytes in Vitro".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.12(2018):3169-3178. |
入库方式： OAI收割
来源：西北高原生物研究所
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