Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats
文献类型：期刊论文
| 作者 | Zheng, Zhenjia4; Zhao, Xian-En3; Zhu, Shuyun3; Dang, Jun1,2; Qiao, Xuguang4; Qiu, Zhichang4; Tao, Yanduo1,2 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2018-04-18 |
| 卷号 | 66期号:15页码:3975-3982 |
| 关键词 | In Vivo Microdialysis Triterpenic Acid Microwave-assisted Derivatization Magnetic Graphene Oxide Pharmacokinetics ArctiumL.ppa L. Root |
| DOI | 10.1021/acs.jafc.7b06015 |
| 英文摘要 | Simultaneous detection of oleanolic acid and ursolic acid in rat blood by in vivo microdialysis can provide important pharmacokinetics information. Microwave-assisted derivatization coupled with magnetic dispersive solid phase extraction was established for the determination of oleanolic acid and ursolic acid by liquid chromatography tandem mass spectrometry. 2'-Carbonyl-piperazine rhodamine B was first designed and synthesized as the derivatization reagent, which was easily adsorbed onto the surface of Fe3O4/graphene oxide. Simultaneous derivatization and extraction of oleanolic acid and ursolic acid were performed on Fe3O4/graphene oxide. The permanent positive charge of the derivatization reagent significantly improved the ionization efficiencies. The limits of detection were 0.025 and 0.020 ng/mL for oleanolic acid and ursolic acid, respectively. The validated method was shown to be promising for sensitive, accurate, and simultaneous determination of oleanolic acid and ursolic acid. It was used for their pharmacokinetics study in rat blood after oral administration of Arctiumlappa L. root extract. |
| 语种 | 英语 |
| WOS记录号 | WOS:000430642200026 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13354]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China 3.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China 4.Shandong Agr Univ, Coll Food Sci & Engn, 61 Daizong St, Tai An 271018, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Zhenjia,Zhao, Xian-En,Zhu, Shuyun,et al. Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(15):3975-3982. |
| APA | Zheng, Zhenjia.,Zhao, Xian-En.,Zhu, Shuyun.,Dang, Jun.,Qiao, Xuguang.,...&Tao, Yanduo.(2018).Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(15),3975-3982. |
| MLA | Zheng, Zhenjia,et al."Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.15(2018):3975-3982. |
入库方式： OAI收割
来源：西北高原生物研究所
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