Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach
文献类型：期刊论文
| 作者 | Fang, Zhongze3,6; Jing, Yu1,2,3; Wu, Xue2,3; Gao, Peng3,4,5; Wu, Jingjing3,4; Wang, Qingjun2,3; Li, Chen2,3; Zhu, Zhitu2,3; Cao, Yunfeng3,4,7 |
| 刊名 | IUBMB LIFE
 |
| 出版日期 | 2017-05-01 |
| 卷号 | 69期号:5页码:347-354 |
| 关键词 | Colorectal Cancer Metabolomics Mass Spectrometry |
| DOI | 10.1002/iub.1617 |
| 英文摘要 | Colorectal cancer (CRC) is the third leading causes of cancermortality, and the early-stage detection could significantly enhance survival rates. Cancer influences the important metabolic pathways and the changes in metabolite levels had been used in many studies as the potential biomarkers. This study is aimed at screening metabolite biomarkers with CRC diagnosis potentials. The direct infusion mass spectrometry (MS) metabolomic analysis based on dried blood spot was used to distinguish CRC from polyp. The target metabolites were composed of 23 amino acids and 26 acylcarnitines. The 21 metabolites in blood were selected via multivariate analysis. A regression model was established based on parameters C16, Arg, C4/C8, C5/C3, Val, Phe/Tyr, Ala, C4/C3. Tenfold cross validation (CV) method was used to test this model and showed sensitivity of 81.18% and specificity of 83.95%. The metabolomic analysis is a practicable method for CRC detection. The use of direct MS analysis in metabolite screening could be finished in several minutes and served as a higher-throughput method to distinguish CRC and polyps. (C) 2017 |
| 语种 | 英语 |
| WOS记录号 | WOS:000399732000009 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/152014]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jinzhou Med Univ, Jinzhou, Liaoning, Peoples R China 2.Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou, Liaoning, Peoples R China 3.KLLTCM, Jinzhou, Liaoning, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China 5.Dalian Sixth Peoples Hosp, Clin Lab, Dalian, Peoples R China 6.Tianjin Med Univ, Sch Publ Hlth, Dept Toxicol, Tianjin, Peoples R China 7.Shanghai Inst Planned Parenthood Res, Key Lab Contracept & Devices Res NPFPC, Shanghai Engineer & Technol Res Ctr Reprod Hlth D, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Zhongze,Jing, Yu,Wu, Xue,et al. Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach[J]. IUBMB LIFE,2017,69(5):347-354. |
| APA | Fang, Zhongze.,Jing, Yu.,Wu, Xue.,Gao, Peng.,Wu, Jingjing.,...&Cao, Yunfeng.(2017).Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach.IUBMB LIFE,69(5),347-354. |
| MLA | Fang, Zhongze,et al."Rapid Differentiating Colorectal Cancer and Colorectal Polyp Using Dried Blood Spot Mass Spectrometry Metabolomic Approach".IUBMB LIFE 69.5(2017):347-354. |
入库方式： OAI收割
来源：大连化学物理研究所
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