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  2. 合肥物质科学研究院
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  4. 技术生物与农业工程研究所
Mutagenicity of ZnO nanoparticles in mammalian cells: Role of physicochemical transformations under the aging process

文献类型：期刊论文

作者Wang, Mei M.1; Wang, Yi C.1; Wang, Xi N.1; Liu, Yun1; Zhang, Hong1; Zhang, Jian W.2; Huang, Qing1; Chen, Shao P.1; Hei, Tom K.3; Wu, Li J.1
刊名NANOTOXICOLOGY
出版日期2015
卷号9期号:8页码:972-982
关键词Aging Process Human-hamster Hybrid (a(l)) Cell Mutagenicity Physicochemical Transformation Zno Nanoparticles
DOI10.3109/17435390.2014.992816
文献子类Article
英文摘要Zinc oxide nanoparticles (ZnO NPs) potentially undergo physicochemical transformation in the environment, which may lead to unexpected environmental and health risks. The "aging'' process is essential for better understanding the toxicity and fate of NPs in the environment. However, the mutagenic effects of aged ZnO NPs are still unexplored. The present study focused on investigating the physicochemical transformation during aging process and clarifying the mutagenicity of naturally aged ZnO NPs in human-hamster hybrid (A(L)) cells. It was found that ZnO NPs underwent sophisticated physicochemical transformations with aging regardless of original morphology or size, such as the microstructural changes, the formation of hydrozincite (Zn-5(CO3)(2)(OH)(6)) and the release of free zinc ions. Interestingly, the aged ZnO NPs were investigated to be able to result in much lower cytotoxicity while relatively high degree mutation than fresh ZnO NPs. With characterization of the soluble and insoluble fractions of aged ZnO NPs suspension, together with the control measurements using metal chelator (TPEN) and endocytosis inhibitor (Nystatin), it was revealed that the release of zinc ions and nanoparticle uptake made significantly different contributions to the mutagenicity of fresh and aged ZnO NPs. This study clearly demonstrated that the physicochemical transformation of ZnO NPs with aging plays important and comprehensive roles in the ZnO NPs-induced mutagenicity in mammalian cells.
WOS关键词ZINC-OXIDE NANOPARTICLES ; ANTIBACTERIAL ACTIVITY ; PARTICLE SOLUBILITY ; DISSOLUTION ; TOXICITY ; OXYGEN ; WATER ; GENOTOXICITY ; SIZE ; PH
WOS研究方向Science & Technology - Other Topics ; Toxicology
语种英语
WOS记录号WOS:000369964300004
资助机构Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; 30570422) ; 30570422) ; 30570422) ; 30570422) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; 30570422) ; 30570422) ; 30570422) ; 30570422)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22290]  
专题合肥物质科学研究院_技术生物与农业工程研究所
作者单位1.Chinese Acad Sci & Anhui Prov, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Phys Sci, Hefei 230026, Peoples R China
3.Columbia Univ, Coll Phys & Surg, Ctr Radiol Res, Dept Radiat Oncol, New York, NY 10027 USA
推荐引用方式
GB/T 7714		 Wang, Mei M.,Wang, Yi C.,Wang, Xi N.,et al. Mutagenicity of ZnO nanoparticles in mammalian cells: Role of physicochemical transformations under the aging process[J]. NANOTOXICOLOGY,2015,9(8):972-982.
APA Wang, Mei M..,Wang, Yi C..,Wang, Xi N..,Liu, Yun.,Zhang, Hong.,...&Xu, An.(2015).Mutagenicity of ZnO nanoparticles in mammalian cells: Role of physicochemical transformations under the aging process.NANOTOXICOLOGY,9(8),972-982.
MLA Wang, Mei M.,et al."Mutagenicity of ZnO nanoparticles in mammalian cells: Role of physicochemical transformations under the aging process".NANOTOXICOLOGY 9.8(2015):972-982.

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来源：合肥物质科学研究院

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