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A polyethylenimine functionalized porous/hollow nanoworm as a drug delivery system and a bioimaging agent

文献类型：期刊论文

作者Sun, Xiao1; Cai, Chuanjie1,2; Wang, Qian3; Cai, Dongqing1; Qian, Junchao4; Chi, Yu1,2; Zheng, Kang5; Zhang, Xin3; Zhang, Guilong1,2; Zhong, Kai4
刊名PHYSICAL CHEMISTRY CHEMICAL PHYSICS
出版日期2016-03-21
卷号18期号:11页码:7820-7828
DOI10.1039/c5cp07933k
文献子类Article
英文摘要A wormstructured and nanosized porous/hollow polyethyleneimine (PEI) functionalized Gd2O3/Fe3O4 composite was fabricated as a drug carrier and a bioimaging agent. The effect of PEI's chain length on the size and morphology of the nanoworm was investigated and the results indicated that the nanoworm modified with PEI (10 000 molecular weight) (designated as p-nanoworm) possessed a suitable size and a porous/hollow structure. Meanwhile, the p-nanoworm could effectively prevent the leakage of Gd ions under different pH conditions because of plenty of amino groups on their surface. Compared with contrast agents of clinical use, the p-nanoworm displayed MR enhancement with a high r(1) relaxivity of 5.58 s(-1) mM(-1) per gadolinium atom. Cisplatin (CDDP), a clinical anticancer drug, could be easily loaded into the pores and lumen of the p-nanoworm (p-nanoworm-CDDP) and also controllably released by adjusting the pH value. Cell assay suggested that the p-nanoworm possessed satisfactory biocompatibility and meanwhile could promote CDDP uptake of HeLa cells and enhance the inhibition effect on HeLa cells. In addition, p-nanoworm-CDDP showed a negligible cytotoxicity on normal human cells, indicating that the side effect of CDDP is reduced. Thus, the p-nanoworm could have a potential application for the diagnosis and therapy of cancer.
WOS关键词MODIFIED MESOPOROUS SILICA ; IRON-OXIDE NANOPROBE ; CONTRAST AGENT ; GD2O3 NANOPARTICLES ; CONTROLLED-RELEASE ; SURFACE-CHEMISTRY ; CARRIER SYSTEM ; CISPLATIN ; HOLLOW ; T-1
WOS研究方向Chemistry ; Physics
语种英语
WOS记录号WOS:000372229700025
资助机构National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Chinese Academy of Sciences(KSZD-EW-Z-022-05 ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; Grant of the President Foundation of Hefei Institutes of Physical Science of Chinese Academy of Sciences(YZJJ201502) ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; U1232212 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; KFJ-EW-STS-083 ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; 81201068) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067) ; KFJ-EW-STS-067)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22331]  
专题合肥物质科学研究院_技术生物与农业工程研究所
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Peoples R China
3.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei 230031, Peoples R China
5.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Xiao,Cai, Chuanjie,Wang, Qian,et al. A polyethylenimine functionalized porous/hollow nanoworm as a drug delivery system and a bioimaging agent[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2016,18(11):7820-7828.
APA Sun, Xiao.,Cai, Chuanjie.,Wang, Qian.,Cai, Dongqing.,Qian, Junchao.,...&Wu, Zhengyan.(2016).A polyethylenimine functionalized porous/hollow nanoworm as a drug delivery system and a bioimaging agent.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,18(11),7820-7828.
MLA Sun, Xiao,et al."A polyethylenimine functionalized porous/hollow nanoworm as a drug delivery system and a bioimaging agent".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 18.11(2016):7820-7828.

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来源：合肥物质科学研究院

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