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  4. 技术生物与农业工程研究所
Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy

文献类型：期刊论文

作者Liu, Yun1; Wang, Xinan1; Wang, Juan1; Nie, Yaguang1; Du, Hua1; Dai, Hui1; Wang, Jingjing1; Wang, Mudi1; Chen, Shaopeng1; Hei, Tom K.2
刊名ENVIRONMENTAL SCIENCE & TECHNOLOGY
出版日期2016-03-15
卷号50期号:6页码:3154-3164
DOI10.1021/acs.est.5b03895
文献子类Article
英文摘要Graphene oxide (GO), owing to its large surface area and abundance of oxygen-containing functional groups, is emerging as a potential adsorbent for polychlorinated biphenyls (PCBs), which accumulate over time and are harmful to both natural ecosystems and human health. However, the effect of GO against PCB-induced toxicity remains largely unexplored. The present study aimed to investigate the protective effect of GO against PCB 52 induced cytotoxic and genotoxic response in mammalian cells at various exposure conditions and clarify the protective role of autophagy. Pretreatment with GO dramatically decreased PCB 52 induced cytotoxicity and CDS9 gene mutation in human hamster hybrid (A(L)) cells. The toxic response in cells either pretreated with PCB 52 and then treated with GO or concurrently treated with GO and PCB 52 did not differ significantly from the toxic response in the cells treated with PCB 52 alone. Using autophagy inhibitors (3-methyladenine and wortmannin) and inducers (trehalose and rapamycin), we found that genuine autophagy induced by GO was involved in decreasing PCB 52 induced toxicity. These findings suggested that GO has an antagonistic effect against the toxicity of PCB 52 mainly by triggering a genuine autophagic process, which might provide new insights into the potential application of GO in PCB disposal and environmental and health risk assessment.
WOS关键词POLYCHLORINATED-BIPHENYLS PCBS ; WALLED CARBON NANOTUBES ; MAMMALIAN-CELLS ROLE ; AQUEOUS-SOLUTION ; SOUTH CHINA ; NANOPARTICLES ; INHIBITION ; EXPOSURE ; BLOOD ; GENOTOXICITY
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000372392100045
资助机构Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; CASHIPS director's fund(YZJJ201501) ; CASHIPS director's fund(YZJJ201501) ; CASHIPS director's fund(YZJJ201501) ; CASHIPS director's fund(YZJJ201501) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; 21177133) ; 21177133) ; 21177133) ; 21177133) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Major National Scientific Research Projects(2014CB932002) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; Strategic Leading Science & Technology Program(XDB14030502) ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; National Natural Science Foundation of China(U1232144 ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology(2014FXCX010) ; CASHIPS director's fund(YZJJ201501) ; CASHIPS director's fund(YZJJ201501) ; CASHIPS director's fund(YZJJ201501) ; CASHIPS director's fund(YZJJ201501) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; 21177133) ; 21177133) ; 21177133) ; 21177133)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/22334]  
专题合肥物质科学研究院_技术生物与农业工程研究所
作者单位1.Chinese Acad Sci & Anhui Prov, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China
2.Columbia Univ, Coll Phys & Surg, Dept Radiat Oncol, Ctr Radiol Res, New York, NY 10032 USA
3.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yun,Wang, Xinan,Wang, Juan,et al. Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2016,50(6):3154-3164.
APA Liu, Yun.,Wang, Xinan.,Wang, Juan.,Nie, Yaguang.,Du, Hua.,...&Xu, An.(2016).Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy.ENVIRONMENTAL SCIENCE & TECHNOLOGY,50(6),3154-3164.
MLA Liu, Yun,et al."Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy".ENVIRONMENTAL SCIENCE & TECHNOLOGY 50.6(2016):3154-3164.

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来源：合肥物质科学研究院

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