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  4. 技术生物与农业工程研究所
Graphene Oxide Modulates B Cell Surface Phenotype and Impairs Immunoglobulin Secretion in Plasma Cell

文献类型：期刊论文

作者Xu, Shaohai1; Xu, Shengmin2; Chen, Shaopeng2; Fan, Huadong1; Luo, Xun2; Yang, Xiaoyao2; Wang, Jun2; Yuan, Hang2; Xu, An2; Wu, Lijun1,2
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
出版日期2016-04-01
卷号16期号:4页码:4205-4215
关键词Graphene Oxide b Cell Phenotype Plasma Cell Immunoglobulin Secretion
DOI10.1166/jnn.2016.11712
文献子类Article
英文摘要Since discovery, graphene oxide (GO) has been used in all aspects of human life and revealed promising applications in biomedicine. Nevertheless, the potential risks of GO were always being revealed. Although GO was found to induce immune cell death and innate immune response, little is known regarding its toxicity to the specific adaptive immune system that is crucial for protecting against exotic invasion. The B-cell mediated adaptive immune system, which composed of highly specialized cells (B and plasma cell) and specific immune response (antibody response) is the focus in our present study. Using diverse standard immunological techniques, we found that GO modulated B cell surface phenotype, both costimulatory molecules (CD80, CD86 and especially CD40) and antigen presenting molecules (both classical and nonclassical) under the condition without causing cell death. Meanwhile, the terminal differentiated immunoglobulin (Ig) secreting plasma cell was affected by GO, which displayed a less secretion of Ig and more severe ER stress caused by the retention of the secreted form of Ig in cell compartment. The combined data reveal that GO has a particular adverse effect to B cell and the humoral immunity, directly demonstrating the potential risk of GO to the specific adaptive immunity.
WOS关键词NF-KAPPA-B ; UNFOLDED PROTEIN RESPONSE ; SIGNALING PATHWAYS ; PRISTINE GRAPHENE ; CARBON NANOTUBES ; IMMUNE-RESPONSES ; EPITHELIAL CD1D ; DENDRITIC CELLS ; T-CELLS ; J-CHAIN
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000386122700192
资助机构National Basic Research Program of China(2014CB932002) ; National Basic Research Program of China(2014CB932002) ; National Basic Research Program of China(2014CB932002) ; National Basic Research Program of China(2014CB932002) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Natural Science Foundation of China(20977093 ; National Natural Science Foundation of China(20977093 ; National Natural Science Foundation of China(20977093 ; National Natural Science Foundation of China(20977093 ; 31470829 ; 31470829 ; 31470829 ; 31470829 ; 81273004) ; 81273004) ; 81273004) ; 81273004) ; National Basic Research Program of China(2014CB932002) ; National Basic Research Program of China(2014CB932002) ; National Basic Research Program of China(2014CB932002) ; National Basic Research Program of China(2014CB932002) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS Strategic Priority Research Program(XDB14030502) ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; CAS/SAFEA International Partnership Program for Creative Research Teams ; National Natural Science Foundation of China(20977093 ; National Natural Science Foundation of China(20977093 ; National Natural Science Foundation of China(20977093 ; National Natural Science Foundation of China(20977093 ; 31470829 ; 31470829 ; 31470829 ; 31470829 ; 81273004) ; 81273004) ; 81273004) ; 81273004)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/30141]  
专题合肥物质科学研究院_技术生物与农业工程研究所
作者单位1.Univ Sci & Technol China, Sch Nucl Sci & Technol, Hefei 230031, Anhui, Peoples R China
2.Chinese Acad Sci & Anhui Prov, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Shaohai,Xu, Shengmin,Chen, Shaopeng,et al. Graphene Oxide Modulates B Cell Surface Phenotype and Impairs Immunoglobulin Secretion in Plasma Cell[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(4):4205-4215.
APA Xu, Shaohai.,Xu, Shengmin.,Chen, Shaopeng.,Fan, Huadong.,Luo, Xun.,...&Wu, Lijun.(2016).Graphene Oxide Modulates B Cell Surface Phenotype and Impairs Immunoglobulin Secretion in Plasma Cell.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(4),4205-4215.
MLA Xu, Shaohai,et al."Graphene Oxide Modulates B Cell Surface Phenotype and Impairs Immunoglobulin Secretion in Plasma Cell".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.4(2016):4205-4215.

入库方式： OAI收割

来源：合肥物质科学研究院

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