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A pivotal role of the jasmonic acid signal pathway in mediating radiation-induced bystander effects in Arabidopsis thaliana

文献类型：期刊论文

作者Wang, Ting1,2; Xu, Wei1,2; Deng, Chenguang1,2; Xu, Shaoxin1,2; Li, Fanghua1,2; Wu, Yuejin1,2; Wu, Lijun1,2; Bian, Po1,2
刊名MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
出版日期2016-09-01
卷号791期号:无页码:1-9
关键词Radiation-induced Bystander Effect Arabidopsis Thaliana Jasmonic Acid Ja Signal Pathway Dna Repair
DOI10.1016/j.mrfmmm.2016.07.002
文献子类Article
英文摘要Although radiation-induced bystander effects (RIBE) in Arabidopsis thaliana have been well demonstrated in vivo, little is known about their underlying mechanisms, particularly with regard to the participating signaling molecules and signaling pathways. In higher plants, jasmonic acid (JA) and its bioactive derivatives are well accepted as systemic signal transducers that are produced in response to various environmental stresses. It is therefore speculated that the JA signal pathway might play a potential role in mediating radiation-induced bystander signaling of root-to-shoot. In the present study, pretreatment of seedlings with Salicylhydroxamic acid, an inhibitor of lipoxigenase (LOX) in JA biosynthesis, significantly suppressed RIBE-mediated expression of the AtRAD54 gene. After root irradiation, the aerial parts of A. thaliana mutants deficient in JA biosynthesis (aos) and signaling cascades (jar1-1) showed suppressed induction of the AtRAD54 and AtRAD51 genes and TSI and 180-bp repeats, which have been extensively used as endpoints of bystander genetic and epigenetic effects in plants. These results suggest an involvement of the JA signal pathway in the RIBE of plants. Using the root micro-grafting technique, the JA signal pathway was shown to participate in both the generation of bystander signals in irradiated root cells and radiation responses in the bystander aerial parts of plants. The over-accumulation of endogenous JA in mutant fatty add oxygenation up-regulated 2 (fou2), in which mutation of the Two Pore Channel 1 (TPC1) gene up-regulates expression of the LOX and allene oxide synthase (AOS) genes, inhibited RIBE-mediated expression of the AtRAD54 gene, but up-regulated expression of the AtKU70 and AtLIG4 genes in the non-homologous end joining (NHEJ) pathway. Considering that NHEJ is employed by plants with increased DNA damage, the switch from HR to NHEJ suggests that over-accumulation of endogenous JA might enhance the radiosensitivity of plants in terms of RIBE. (C) 2016 Elsevier B.V. All tights reserved.
WOS关键词EFFECTS IN-VIVO ; IONIZING-RADIATION ; MICROBEAM IRRADIATION ; TARGETED IRRADIATION ; GENOMIC INSTABILITY ; EPIGENETIC EFFECTORS ; UROTHELIAL EXPLANTS ; METHYL JASMONATE ; SALICYLIC-ACID ; WOUND RESPONSE
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
语种英语
WOS记录号WOS:000386191500001
资助机构National Science Fund of China(11275230 ; National Science Fund of China(11275230 ; National Science Fund of China(11275230 ; National Science Fund of China(11275230 ; 11575233 ; 11575233 ; 11575233 ; 11575233 ; U1332127) ; U1332127) ; U1332127) ; U1332127) ; National Science Fund of China(11275230 ; National Science Fund of China(11275230 ; National Science Fund of China(11275230 ; National Science Fund of China(11275230 ; 11575233 ; 11575233 ; 11575233 ; 11575233 ; U1332127) ; U1332127) ; U1332127) ; U1332127)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/30147]  
专题合肥物质科学研究院_技术生物与农业工程研究所
作者单位1.Chinese Acad Sci, Key Lab Ion Beam Bioengn, Hefei Inst Phys Sci, Hefei 230031, Peoples R China
2.Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Ting,Xu, Wei,Deng, Chenguang,et al. A pivotal role of the jasmonic acid signal pathway in mediating radiation-induced bystander effects in Arabidopsis thaliana[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,2016,791(无):1-9.
APA Wang, Ting.,Xu, Wei.,Deng, Chenguang.,Xu, Shaoxin.,Li, Fanghua.,...&Bian, Po.(2016).A pivotal role of the jasmonic acid signal pathway in mediating radiation-induced bystander effects in Arabidopsis thaliana.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,791(无),1-9.
MLA Wang, Ting,et al."A pivotal role of the jasmonic acid signal pathway in mediating radiation-induced bystander effects in Arabidopsis thaliana".MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 791.无(2016):1-9.

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来源：合肥物质科学研究院

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