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Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans

文献类型：期刊论文

作者Luo, Xun1,2,3; Xu, Shengmin1,4; Yang, Yaning1,2; Li, Luzhi1,4; Chen, Shaopeng1,4; Xu, An1,4; Wu, Lijun1,2,4
刊名SCIENTIFIC REPORTS
出版日期2016-11-04
卷号6期号:无页码:1-12
DOI10.1038/srep36465
文献子类Article
英文摘要Previous studies have indicated that engineered nanomaterials can be transferred through the food chain. However, their potential ecotoxicity to the environment is not fully understood. Here, we systematically evaluated the physiological behavior and toxicity of polyvinylpyrrolidone (PVP)-coated silver nanoparticles (AgNPs) using a food chain model from Escherichia coli (E. coli) to Caenorhabditis elegans (C. elegans). Our results demonstrated that AgNPs accumulated in E. coli could be transferred to the C. elegans, and AgNPs were clearly distributed in the gut lumen, subcutaneous tissue and gonad. After being transferred to C. elegans through the food chain, the accumulated AgNPs caused serious toxicity to the higher trophic level (C. elegans), including effects on germ cell death, reproductive integrity and life span. Relative to larger particles (75 nm), small AgNPs (25 nm) more easily accumulated in the food chain and exhibited a stronger toxicity to the higher trophic level. More importantly, both the AgNPs that had accumulated in C. elegans through the food chain and the resulting impairment of germ cells could be transferred to the next generation, indicating that AgNP can cause genetic damage across generations. Our findings highlight that nanomaterials pose potential ecotoxicity to ecosystems via transport through the food chain.
WOS关键词DNA-DAMAGE RESPONSE ; FOOD-CHAIN ; ENGINEERED NANOPARTICLES ; DAPHNIA-MAGNA ; QUANTUM DOTS ; TOXICITY ; SIZE ; CELL ; NANOSILVER ; IMPACT
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000387022700001
资助机构National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; National Basic Research 973 Program(2014CB932002) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB14030502) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182) ; National Natural Science Foundation of China(81301182)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/30159]  
专题合肥物质科学研究院_技术生物与农业工程研究所
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
3.Huainan Normal Univ, Sch Bioengn, Huainan 232038, Peoples R China
4.Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Luo, Xun,Xu, Shengmin,Yang, Yaning,et al. Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans[J]. SCIENTIFIC REPORTS,2016,6(无):1-12.
APA Luo, Xun.,Xu, Shengmin.,Yang, Yaning.,Li, Luzhi.,Chen, Shaopeng.,...&Wu, Lijun.(2016).Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans.SCIENTIFIC REPORTS,6(无),1-12.
MLA Luo, Xun,et al."Insights into the Ecotoxicity of Silver Nanoparticles Transferred from Escherichia coli to Caenorhabditis elegans".SCIENTIFIC REPORTS 6.无(2016):1-12.

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来源：合肥物质科学研究院

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