中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 中科院强磁场科学中心
Biocompatible Chitosan-Carbon Dot Hybrid Nanogels for NIR-Imaging-Guided Synergistic Photothermal-Chemo Therapy

文献类型：期刊论文

作者Wang, Hui1,2,3; Mukherjee, Sumit1,2; Ji, Jinhui1,2; Banerjee, Probal1,2; Chen, Qianwang3; Zhou, Shuiqin1,2
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2017-06-07
卷号9期号:22页码:18639-18649
关键词Carbon Dots Chitosan Cchns Responsive Release Nir Imaging
DOI10.1021/acsami.7b06062
文献子类Article
英文摘要Multifunctional nanocarriers with good bio-compatibility, good imaging function, and smart drug delivery ability are crucial for realizing highly efficient imaging-guided chemotherapy in vivo. This paper reports a type of chitosan-carbon dot (CD) hybrid nanogels (CCHNs, similar to 65 nm) by integrating pH-sensitive chitosan and fluorescent CDs into a single nanostructure for simultaneous near-infrared (NIR) imaging and NIR/pH dual-responsive drug release to iinpitove, therapeutic;efficacy. Such CCHNs were synthesized via a nonsolvent-induced colloidal narioparticle formation of chitosan-CD complexes assisted by ethylenediaminetetraacetic acid (EDTA) molecules in the aqueous phase. The selective cross-linking, of chitosan chains in the nanoparticles can immobilize small CDs complexed in the chitosan networks.. The resultant CCHNs display high colloidal stability, high loading capacity for doxorubicin (DOX); bright and stable fluorescence from UV to NIR wavelength range, efficient NIR photothermal conversion) and intelligent drug release in response to both NIR light and change in pH. The results: from in vitro tests on cell model and in vivo tests on different tissues of animal model indicate that the CCHNs are nontoxic. The DOX-loaded CCHNs can permeate into the implanted tumor on mice and release drug molecules efficiently on site to inhibit tumor growth. The additional photothermal treatments from NIR irradiation can further inhibit the tumor growth,,benefited from the effective NIR photothermal conversion of CCHNs. The demonstrated CCHNs Manifest a great promise toward multifunctional intelligent nannplatform for highly efficient imaging-guided cancer therapy with low side effects.
WOS关键词RESPONSIVE DRUG CARRIER ; GRAPHENE QUANTUM DOTS ; CANCER-THERAPY ; CONTROLLED-RELEASE ; ANTICANCER DRUG ; IN-VIVO ; SILICA SHELL ; DELIVERY ; NANOPARTICLES ; NANOCAPSULES
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000403136400028
资助机构PSC-CUNY Research Award ; PSC-CUNY Research Award ; PSC-CUNY Research Award ; PSC-CUNY Research Award ; American Diabetes Association(1-12-BS-243) ; American Diabetes Association(1-12-BS-243) ; American Diabetes Association(1-12-BS-243) ; American Diabetes Association(1-12-BS-243) ; PSC-CUNY Research Award ; PSC-CUNY Research Award ; PSC-CUNY Research Award ; PSC-CUNY Research Award ; American Diabetes Association(1-12-BS-243) ; American Diabetes Association(1-12-BS-243) ; American Diabetes Association(1-12-BS-243) ; American Diabetes Association(1-12-BS-243)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/31919]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.CUNY Coll Staten Isl, Dept Chem, Staten Isl, NY 10314 USA
2.CUNY, Grad Ctr, PhD Program Biochem & Chem, New York, NY 10016 USA
3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hui,Mukherjee, Sumit,Ji, Jinhui,et al. Biocompatible Chitosan-Carbon Dot Hybrid Nanogels for NIR-Imaging-Guided Synergistic Photothermal-Chemo Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18639-18649.
APA Wang, Hui,Mukherjee, Sumit,Ji, Jinhui,Banerjee, Probal,Chen, Qianwang,&Zhou, Shuiqin.(2017).Biocompatible Chitosan-Carbon Dot Hybrid Nanogels for NIR-Imaging-Guided Synergistic Photothermal-Chemo Therapy.ACS APPLIED MATERIALS & INTERFACES,9(22),18639-18649.
MLA Wang, Hui,et al."Biocompatible Chitosan-Carbon Dot Hybrid Nanogels for NIR-Imaging-Guided Synergistic Photothermal-Chemo Therapy".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18639-18649.

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。