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Rutin ameliorates obesity through brown fat activation

文献类型：期刊论文

作者Yuan, Xiaoxue1,3; Wei, Gang1,3; You, Yilin4; Huang, Yuanyuan1,3; Lee, Hyuek Jong1; Dong, Meng1,3; Lin, Jun1,3; Hu, Tao1,3; Zhang, Hanlin1; Zhang, Chuanhai1
刊名FASEB JOURNAL
出版日期2017
卷号31期号:1页码:333-+
关键词Brown Adipose Tissue Rutin Obesity Energy Expenditure Mitochondria
DOI10.1096/fj.201600459RR
文献子类Article
英文摘要Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, a natural compound extracted from mulberry and a drug used as a capillary stabilizer clinically for many years without any side effects, regulated whole-body energy metabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased energy expenditure, and improved glucose homeostasis in both genetically obese (Db/Db) and diet-induced obesity (DIO) mice. Rutin also induced brown-like adipocyte (beige) formation in subcutaneous adipose tissue in both obesity mouse models. Mechanistically, we found that rutin directly bound to and stabilized SIRT1, leading to hypoacetylation of peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, which stimulated Tfam transactivation and eventually augmented the number of mitochondria and UCP1 activity in BAT. These findings reveal that rutin is a novel small molecule that activates BAT and may provide a novel therapeutic approach to the treatment of metabolic disorders.-Yuan, X., Wei, G., You, Y., Huang, Y., Lee, H. J., Dong, M., Lin, J., Hu, T., Zhang, H., Zhang, C., Zhou, H., Ye, R., Qi, X., Zhai, B., Huang, W., Liu, S., Xie, W., Liu, Q., Liu, X., Cui, C., Li, D., Zhan, J., Cheng, J., Yuan, Z., Jin, W. Rutin ameliorates obesity through brown fat activation.
WOS关键词ADIPOSE-TISSUE THERMOGENESIS ; DIET-INDUCED OBESITY ; GLUCOSE-HOMEOSTASIS ; INSULIN SENSITIVITY ; ADULT HUMANS ; WHITE FAT ; SIRT1 ; MICE ; RESVERATROL ; METABOLISM
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种英语
WOS记录号WOS:000392177600031
资助机构Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; CAS, One Hundred Talents Program of the CAS ; CAS, One Hundred Talents Program of the CAS ; CAS, One Hundred Talents Program of the CAS ; CAS, One Hundred Talents Program of the CAS ; Ministry of Science and Technology of China(2012CBA01301 ; Ministry of Science and Technology of China(2012CBA01301 ; Ministry of Science and Technology of China(2012CBA01301 ; Ministry of Science and Technology of China(2012CBA01301 ; National Natural Science Foundation of China(31171131 ; National Natural Science Foundation of China(31171131 ; National Natural Science Foundation of China(31171131 ; National Natural Science Foundation of China(31171131 ; National Basic Research Program of China(2012CB910701 ; National Basic Research Program of China(2012CB910701 ; National Basic Research Program of China(2012CB910701 ; National Basic Research Program of China(2012CB910701 ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; 2015CB943102 ; 2015CB943102 ; 2015CB943102 ; 2015CB943102 ; 81370951 ; 81370951 ; 81370951 ; 81370951 ; 2013DFA31990) ; 2013DFA31990) ; 2013DFA31990) ; 2013DFA31990) ; 2012BAD31B05) ; 2012BAD31B05) ; 2012BAD31B05) ; 2012BAD31B05) ; 2012CB944701) ; 2012CB944701) ; 2012CB944701) ; 2012CB944701) ; 81500659) ; 81500659) ; 81500659) ; 81500659) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Strategic Priority Research Program(XDB13030000) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; Key Research Program(KJZD-EW-L01-3) ; CAS, One Hundred Talents Program of the CAS ; CAS, One Hundred Talents Program of the CAS ; CAS, One Hundred Talents Program of the CAS ; CAS, One Hundred Talents Program of the CAS ; Ministry of Science and Technology of China(2012CBA01301 ; Ministry of Science and Technology of China(2012CBA01301 ; Ministry of Science and Technology of China(2012CBA01301 ; Ministry of Science and Technology of China(2012CBA01301 ; National Natural Science Foundation of China(31171131 ; National Natural Science Foundation of China(31171131 ; National Natural Science Foundation of China(31171131 ; National Natural Science Foundation of China(31171131 ; National Basic Research Program of China(2012CB910701 ; National Basic Research Program of China(2012CB910701 ; National Basic Research Program of China(2012CB910701 ; National Basic Research Program of China(2012CB910701 ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; Beijing Municipal Administration of Hospitals(ZYLX201402) ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; National "Twelfth Five-Year" Plan for Science and Technology Support Grants(2012BAD31B07 ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; Special Fund for Agro-scientific Research in the Public Interest Grant(201303073-2) ; 2015CB943102 ; 2015CB943102 ; 2015CB943102 ; 2015CB943102 ; 81370951 ; 81370951 ; 81370951 ; 81370951 ; 2013DFA31990) ; 2013DFA31990) ; 2013DFA31990) ; 2013DFA31990) ; 2012BAD31B05) ; 2012BAD31B05) ; 2012BAD31B05) ; 2012BAD31B05) ; 2012CB944701) ; 2012CB944701) ; 2012CB944701) ; 2012CB944701) ; 81500659) ; 81500659) ; 81500659) ; 81500659)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/32796]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Food Sci & Nutr Engn, Beijing, Peoples R China
5.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing, Peoples R China
6.Chinese Acad Sci, High Magnet Field Lab, Hefei, Peoples R China
7.Zhoukou Normal Univ, Coll Life Sci, Zhoukou, Henan, Peoples R China
8.Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Yanji, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Xiaoxue,Wei, Gang,You, Yilin,et al. Rutin ameliorates obesity through brown fat activation[J]. FASEB JOURNAL,2017,31(1):333-+.
APA Yuan, Xiaoxue.,Wei, Gang.,You, Yilin.,Huang, Yuanyuan.,Lee, Hyuek Jong.,...&Jin, Wanzhu.(2017).Rutin ameliorates obesity through brown fat activation.FASEB JOURNAL,31(1),333-+.
MLA Yuan, Xiaoxue,et al."Rutin ameliorates obesity through brown fat activation".FASEB JOURNAL 31.1(2017):333-+.

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来源：合肥物质科学研究院

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