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Cell type- and density-dependent effect of 1 T static magnetic field on cell proliferation

文献类型：期刊论文

作者Zhang, Lei1,2; Ji, Xinmiao1; Yang, Xingxing1; Zhang, Xin1
刊名ONCOTARGET
出版日期2017
卷号8期号:8页码:13126-13141
关键词Static Magnetic Field Cancer Cell Egfr
DOI10.18632/oncotarget.14480
文献子类Article
英文摘要Increasing evidence shows that static magnetic fields (SMFs) can affect cell proliferation but mixed results have been reported. Here we systematically examined the effects of 1 T (Tesla) SMF, which is close to the SMF intensity that patients are exposed to MRI (magnetic resonance imaging) scanners in hospitals, for its effect on 15 different cell lines, including 12 human and 3 rodent cell lines. Our results show that 1 T SMF does not have apparent impact on cell cycle or cell death. However, at higher cell density, it reduced cell numbers in six out of seven solid human cancer cell lines. We found that both cell type and cell density had evident impacts on SMF effects. Moreover, the EGFR-Akt-mTOR pathway, which varies significantly between different cell types and densities, contributes to the differential effects of SMF. In addition, SMF also increases the efficacy of Akt inhibitors on cancer cell growth inhibition. Therefore 1 T SMF affects cell proliferation in a cell type-and cell density-dependent manner, and the inhibition effect of 1 T SMF on multiple cancer cells at higher cell density may indicate its clinical potential in late stage cancer therapy.
WOS关键词TYROSINE KINASE INHIBITOR ; ANTITUMOR EFFICACY ; IN-VITRO ; LUNG-CANCER ; GROWTH ; RECEPTOR ; EXPOSURE ; FIBROBLASTS ; ADHESION ; VIVO
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000395692000059
资助机构National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; Hefei Science Center CAS(2016HSC-IU007) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; National Natural Science Foundation of China(U1532151) ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility ; Chinese High Magnetic Field Laboratory facility
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/32869]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Lei,Ji, Xinmiao,Yang, Xingxing,et al. Cell type- and density-dependent effect of 1 T static magnetic field on cell proliferation[J]. ONCOTARGET,2017,8(8):13126-13141.
APA Zhang, Lei,Ji, Xinmiao,Yang, Xingxing,&Zhang, Xin.(2017).Cell type- and density-dependent effect of 1 T static magnetic field on cell proliferation.ONCOTARGET,8(8),13126-13141.
MLA Zhang, Lei,et al."Cell type- and density-dependent effect of 1 T static magnetic field on cell proliferation".ONCOTARGET 8.8(2017):13126-13141.

入库方式： OAI收割

来源：合肥物质科学研究院

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