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High-Frequency Mechanostimulation of Cell Adhesion

文献类型：期刊论文

作者Kadem, Laith F.1; Suana, K. Grace2; Holz, Michelle2; Wang, Wei1,3; Westerhaus, Hannes1; Herges, Rainer2; Selhuber-Unkel, Christine1
刊名ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期2017-01-02
卷号56期号:1页码:225-229
关键词Azobenzene Cell Adhesion Integrins Mechanosensing Single-cell Force Spectroscopy
DOI10.1002/anie.201609483
文献子类Article
英文摘要Cell adhesion is regulated by molecularly defined protein interactions and by mechanical forces, which can activate a dynamic restructuring of adhesion sites. Previous attempts to explore the response of cell adhesion to forces have been limited to applying mechanical stimuli that involve the cytoskeleton. In contrast, we here apply a new, oscillatory type of stimulus through push-pull azobenzenes. Push-pull azobenzenes perform a high-frequency, molecular oscillation upon irradiation with visible light that has frequently been applied in polymer surface relief grating. We here use these oscillations to address single adhesion receptors. The effect of molecular oscillatory forces on cell adhesion has been analyzed using single-cell force spectroscopy and gene expression studies. Our experiments demonstrate a reinforcement of cell adhesion as well as upregulated expression levels of adhesion-associated genes as a result of the nanoscale "tickling" of integrins. This novel type of mechanical stimulus provides a previously unprecedented molecular control of cellular mechanosensing.
WOS关键词Z-E ISOMERIZATION ; TRANS ISOMERIZATION ; AZOBENZENES ; SOLVENT ; SUBSTITUENT ; PRESSURE ; INTEGRIN ; MOTION
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000394861200030
资助机构Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; Deutsche Forschungsgemeinschaft(SFB 677 ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; European Research Council(336104) ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; SE 1801/2-1 ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1) ; INST 257/407-1)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/32876]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Univ Kiel, Inst Mat Sci, Kaiserstr 2, D-24143 Kiel, Germany
2.Univ Kiel, Otto Diels Inst Organ Chem, Otto Hahn Pl 4, Kiel, Germany
3.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Kadem, Laith F.,Suana, K. Grace,Holz, Michelle,et al. High-Frequency Mechanostimulation of Cell Adhesion[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(1):225-229.
APA Kadem, Laith F..,Suana, K. Grace.,Holz, Michelle.,Wang, Wei.,Westerhaus, Hannes.,...&Selhuber-Unkel, Christine.(2017).High-Frequency Mechanostimulation of Cell Adhesion.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(1),225-229.
MLA Kadem, Laith F.,et al."High-Frequency Mechanostimulation of Cell Adhesion".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.1(2017):225-229.

入库方式： OAI收割

来源：合肥物质科学研究院

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