中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 中科院强磁场科学中心
STK16 regulates actin dynamics to control Golgi organization and cell cycle

文献类型：期刊论文

作者Liu, Juanjuan1,2; Yang, Xingxing1; Li, Binhua1; Wang, Junjun1,2; Wang, Wenchao1; Liu, Jing1; Liu, Qingsong1,2; Zhang, Xin1
刊名SCIENTIFIC REPORTS
出版日期2017-03-15
卷号7期号:无页码:1-17
DOI10.1038/srep44607
文献子类Article
英文摘要STK16 is a ubiquitously expressed, myristoylated, and palmitoylated serine/threonine protein kinase with underexplored functions. Recently, it was shown to be involved in cell division but the mechanism remains unclear. Here we found that human STK16 localizes to the Golgi complex throughout the cell cycle and plays important roles in Golgi structure regulation. STK16 knockdown or kinase inhibition disrupts actin polymers and causes fragmented Golgi in cells. In vitro assays show that STK16 directly binds to actin and regulates actin dynamics in a concentration- and kinase activity-dependent way. In addition, STK16 knockdown or kinase inhibition not only delays mitotic entry and prolongs mitosis, but also causes prometaphase and cytokinesis arrest. Therefore, we revealed STK16 as a novel actin binding protein that resides in the Golgi, which regulates actin dynamics to control Golgi structure and participate in cell cycle progression.
WOS关键词MAMMALIAN-CELLS ; PROTEIN-KINASE ; CENTROSOME SEPARATION ; ENDOPLASMIC-RETICULUM ; SPINDLE ORIENTATION ; COMPLEX ; FILAMENTS ; CYTOSKELETON ; PHOSPHORYLATION ; MICROTUBULES
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000396342800001
资助机构National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; National Natural Science Foundation of China(31301112) ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program" ; Chinese Academy of Sciences "Hundred Talent program"
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/32891]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Juanjuan,Yang, Xingxing,Li, Binhua,et al. STK16 regulates actin dynamics to control Golgi organization and cell cycle[J]. SCIENTIFIC REPORTS,2017,7(无):1-17.
APA Liu, Juanjuan.,Yang, Xingxing.,Li, Binhua.,Wang, Junjun.,Wang, Wenchao.,...&Zhang, Xin.(2017).STK16 regulates actin dynamics to control Golgi organization and cell cycle.SCIENTIFIC REPORTS,7(无),1-17.
MLA Liu, Juanjuan,et al."STK16 regulates actin dynamics to control Golgi organization and cell cycle".SCIENTIFIC REPORTS 7.无(2017):1-17.

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。