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Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T

文献类型：期刊论文

作者He, Genxia1,2; Qian, Junchao3
刊名MICROSCOPY RESEARCH AND TECHNIQUE
出版日期2017-09-01
卷号80期号:9页码:1009-1017
关键词Brain Axonal Integrity Phase Imaging Rats Spinal Cord Injury 9.4 t
DOI10.1002/jemt.22895
文献子类Article
英文摘要It was known that Spinal cord injury (SCI) leads to neuronal cell death, axonal damage and demyelination, and often results in severe functional loss. Noninvasive imaging of axonal integrity may hold great importance in clinic. This study evaluated the role of phase imaging in detection of axonal integrity of cranial corticospinal tract after spinal cord injury. Quantitative MR phase imaging and diffusion tensor imaging were performed on a group of rats prior to and after spinal cord injury at 9.4 T in this study. The phase contrast decreased mainly in contralateral white matter containing the corticospinal tract (CST), i.e., pyramid by 46%, two weeks postinjury compared to preinjury levels. Diffusion measurements further showed fractional anisotropy (FA) increased and radial diffusivity (perpendicular to) decreased significantly, and axial diffusivity (vertical bar) remained unchanged in these regions confirmed intact fiber tracts two weeks after injury, precluding the possibility of axonal damage and potential contribution to the shifted susceptibility. It was concluded that phase imaging is a potential endogenous biomarker for brain axonal integrity after spinal cord injury. This novel tool could potentially be applied to diagnose brain pathologies in patients who have spinal cord injury.
WOS关键词WHITE-MATTER CONTRAST ; GRADIENT-ECHO MRI ; HIGH-FIELD MRI ; BIOPHYSICAL MECHANISMS ; MULTIPLE-SCLEROSIS ; FIBER ORIENTATION ; MOTOR CORTEX ; BRAIN-TISSUE ; IRON CONTENT ; REORGANIZATION
WOS研究方向Anatomy & Morphology ; Life Sciences & Biomedicine - Other Topics ; Microscopy
语种英语
WOS记录号WOS:000407928600005
资助机构National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068) ; National Natural Science Foundation of China(81201068)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/33556]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Anhui 2 Prov Peoples Hosp, Dept Neurol, Hefei, Anhui, Peoples R China
2.Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 He, Genxia,Qian, Junchao. Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T[J]. MICROSCOPY RESEARCH AND TECHNIQUE,2017,80(9):1009-1017.
APA He, Genxia,&Qian, Junchao.(2017).Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T.MICROSCOPY RESEARCH AND TECHNIQUE,80(9),1009-1017.
MLA He, Genxia,et al."Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T".MICROSCOPY RESEARCH AND TECHNIQUE 80.9(2017):1009-1017.

入库方式： OAI收割

来源：合肥物质科学研究院

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