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  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 技术生物与农业工程研究所
A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy

文献类型：期刊论文

作者Sun, Xiao1,2; Du, Ruohong3; Zhang, Li4; Zhang, Guilong1; Zheng, Xiaojia5; Qian, Junchao7; Tian, Xiaohe8; Zhou, Jiewen6; He, Jiacai5; Wang, Yuanyin5
刊名ACS NANO
出版日期2017-07-01
卷号11期号:7页码:7049-7059
关键词Yolk-like Fe3o4@gd2o3 Targeted Dual-mode Mr Imaging Drug Delivery System Cisplatin Ph Responsive Cancer Chemotherapy
DOI10.1021/acsnano.7b02675
文献子类Article
英文摘要Incorporation of T-1 and T-2 contrast material in one nanosystem performing their respective MR contrast role and simultaneously serving as an efficient drug delivery system (DDS) has a significant potential application for clinical diagnosis and chemotherapy of cancer. However, inappropriate incorporation always encountered many issues, such as low contact area of T-1 contrast material with water-proton, inappropriate distance between T-2 contrast material and water molecule, and undesirable disturbance of T-2 contrast material for T-1 imaging. Those issues seriously limited the T-1 or T-2 contrast effect. In this work, we developed a yolk-like Fe3O4@Gd2O3 nanoplatform functionalized by polyethylene glycol and folic acid (FA), which could efficiently exert their tumor targeted T-1-T-2 dual-mode MR imaging and drug delivery role. First, this nanoplatform possessed a high longitudinal relaxation rate (r(1)) (7.91 mM(-1) s(-1)) and a stronger transverse relaxation rate (r(2)) (386.5 mM(-1) s(-1)) than that of original Fe3O4 (268.1 mM(-1) s(-1)). Second, cisplatin could be efficiently loaded into this nanoplatform (112 mg/g) and showed pH-responsive release behavior. Third, this nanoplatform could be effectively internalized by HeLa cells with time and dosage dependence. Fourth, the FA receptor-mediated nanoplatform displayed excellent T-1-T-2 dual mode MR contrast enhancement and anticancer activity both in vitro and in vivo. Fifth, no apparent toxicity for vital organs was observed with systemic delivery of the nanoplatform in vivo. Thus, this nanoplatform could be a potential nanotheranostic for tumor targeted T-1-T-2 dual-mode MR imaging and chemotherapy.
WOS关键词DRUG-DELIVERY SYSTEM ; MRI CONTRAST AGENTS ; IRON-OXIDE NANOPARTICLES ; BIOIMAGING AGENT ; FACILE SYNTHESIS ; T-1 ; GADOLINIUM ; SURFACE ; ANGIOGRAPHY ; RELAXATION
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000406649700053
资助机构National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; National Natural Science Foundation of China(21407151 ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; Key Program of Chinese Academy of Sciences(KSZD-EW-Z-022-05) ; 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源URL[http://ir.hfcas.ac.cn:8080/handle/334002/33584]  
专题合肥物质科学研究院_技术生物与农业工程研究所
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Anhui, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 1, Dept Stomatol, Hefei 230022, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei 230022, Anhui, Peoples R China
5.Anhui Med Univ, Key Lab Oral Dis Res Anhui Prov, Stomatol Hosp & Coll, Dent Implant Ctr, Hefei 230032, Anhui, Peoples R China
6.Shanghai Jiao Tong Univ, Peoples Hosp 9, Shanghai Key Lab Stomatol, Dent Clin 2,Sch Med, Shanghai 200001, Peoples R China
7.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
8.Anhui Univ, Sch Life Sci, Hefei 230601, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Xiao,Du, Ruohong,Zhang, Li,et al. A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy[J]. ACS NANO,2017,11(7):7049-7059.
APA Sun, Xiao.,Du, Ruohong.,Zhang, Li.,Zhang, Guilong.,Zheng, Xiaojia.,...&Wu, Zhengyan.(2017).A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy.ACS NANO,11(7),7049-7059.
MLA Sun, Xiao,et al."A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy".ACS NANO 11.7(2017):7049-7059.

入库方式： OAI收割

来源：合肥物质科学研究院

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