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Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield

文献类型：期刊论文

作者Wang, Shuansuo1; Wu, Kun2,3; Qian, Qian4; Liu, Qian1; Li, Qi1; Pan, Yajun1; Ye, Yafeng1; Liu, Xueying1; Wang, Jing1; Zhang, Jianqing1
刊名CELL RESEARCH
出版日期2017-09-01
卷号27期号:9页码:1142-1156
关键词New Plant Type Rice Osotub1 Deubiquitination Osspl14 Grain Yield
DOI10.1038/cr.2017.98
文献子类Article
英文摘要Achieving increased grain productivity has long been the overriding focus of cereal breeding programs. The ideotype approach has been used to improve rice yield potential at the International Rice Research Institute and in China. However, the genetic basis of yield-related traits in rice remains unclear. Here, we show that a major quantitative trait locus, qNPT1, acts through the determination of a 'new plant type' (NPT) architecture characterized by fewer tillers, sturdier culms and larger panicles, and it encodes a deubiquitinating enzyme with homology to human OTUB1. Downregulation of OsOTUB1 enhances meristematic activity, resulting in reduced tiller number, increased grain number, enhanced grain weight and a consequent increase in grain yield in rice. Unlike human OTUB1, OsOTUB1 can cleave both K48- and K63-linked polyubiquitin. OsOTUB1 interacts with the E2 ubiquitin-conjugating protein OsUBC13 and the squamosa promoter-binding protein-like transcription factor OsSPL14. OsOTUB1 and OsSPL14 share common target genes, and their physical interaction limits K63-linked ubiquitination (K63Ub) of OsSPL14, which in turn promotes K48Ub-dependent proteasomal degradation of OsSPL14. Conversely, loss-of-function of OsOTUB1 is correlated with the accumulation of high levels of OsSPL14, resulting in the NPT architecture. We also demonstrated that pyramiding of high-yielding npt1 and dep1-1 alleles provides a new strategy for increasing rice yield potential above what is currently achievable.
WOS关键词NATURAL VARIATION ; GREEN-REVOLUTION ; INCREASES YIELD ; USE EFFICIENCY ; ARABIDOPSIS ; PROTEIN ; UBIQUITINATION ; ARCHITECTURE ; GENE ; INHIBITION
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000408916300009
资助机构National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; National Key Research and Development Program of China(2016YFD0100401) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; Chinese Academy of Sciences(XDA08010101) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302) ; National Natural Science Foundation of China(91635302)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/33620]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位1.Chinese Acad Sci, Natl Ctr Plant Gene Res, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
3.Univ Sci & Technol China, Sch Life Sci, Hefei 230000, Anhui, Peoples R China
4.China Natl Rice Res Inst, Key Lab Rice Biol, Hangzhou 310006, Zhejiang, Peoples R China
5.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Shuansuo,Wu, Kun,Qian, Qian,et al. Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield[J]. CELL RESEARCH,2017,27(9):1142-1156.
APA Wang, Shuansuo.,Wu, Kun.,Qian, Qian.,Liu, Qian.,Li, Qi.,...&Fu, Xiangdong.(2017).Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield.CELL RESEARCH,27(9),1142-1156.
MLA Wang, Shuansuo,et al."Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield".CELL RESEARCH 27.9(2017):1142-1156.

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来源：合肥物质科学研究院

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