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Kinases Involved in Both Autophagy and Mitosis

文献类型：期刊论文

作者Li, Zhiyuan; Zhang, Xin
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2017-09-01
卷号18期号:9页码:1-15
关键词Kinases Autophagy Mitosis Cyclin-dependent Kinases Aurora Polo-like Kinases
DOI10.3390/ijms18091884
文献子类Review
英文摘要Both mitosis and autophagy are highly regulated dynamic cellular processes and involve various phosphorylation events catalysed by kinases, which play vital roles in almost all physiological and pathological conditions. Mitosis is a key event during the cell cycle, in which the cell divides into two daughter cells. Autophagy is a process in which the cell digests its own cellular contents. Although autophagy regulation has mainly been studied in asynchronous cells, increasing evidence indicates that autophagy is in fact tightly regulated in mitosis. Here in this review, we will discuss kinases that were originally identified to be involved in only one of either mitosis or autophagy, but were later found to participate in both processes, such as CDKs (cyclin-dependent kinases), Aurora kinases, PLK-1 (polo-like kinase 1), BUB1 (budding uninhibited by benzimidazoles 1), MAPKs (mitogen-activated protein kinases), mTORC1 (mechanistic target of rapamycin complex 1), AMPK (AMP-activated protein kinase), PI3K (phosphoinositide-3 kinase) and protein kinase B (AKT). By focusing on kinases involved in both autophagy and mitosis, we will get a more comprehensive understanding about the reciprocal regulation between the two key cellular events, which will also shed light on their related therapeutic investigations.
WOS关键词CONSERVED CDC2-RELATED KINASE ; SISTER-CHROMATID COHESION ; CELL-CYCLE ARREST ; CANCER-CELLS ; P38 MAPK ; SIGNALING PATHWAYS ; AURORA KINASE ; MEDIATED PHOSPHORYLATION ; MESENCHYMAL TRANSITION ; MITOTIC PROGRESSION
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000411963800063
资助机构National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; National Key Research and Development Program of China(2016YFA0400900) ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045) ; China Postdoctoral Science Foundation(2016M602045)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/33798]  
专题合肥物质科学研究院_中科院强磁场科学中心
作者单位Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Li, Zhiyuan,Zhang, Xin. Kinases Involved in Both Autophagy and Mitosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(9):1-15.
APA Li, Zhiyuan,&Zhang, Xin.(2017).Kinases Involved in Both Autophagy and Mitosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(9),1-15.
MLA Li, Zhiyuan,et al."Kinases Involved in Both Autophagy and Mitosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.9(2017):1-15.

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来源：合肥物质科学研究院

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