中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 中国科学院核能安全技术研究所
Biological effects of human lung cells MRC-5 in CBCT positioning for image-guided radiotherapy

文献类型：期刊论文

作者Jin, Chu-Feng1,2; Liu, Hui2; Li, Wen-Yi2; Cao, Rui-Fen2
刊名NUCLEAR SCIENCE AND TECHNIQUES
出版日期2017-05-01
卷号28期号:5页码:1-5
关键词Image-guided Radiotherapy Cone Beam Ct Imaging Irradiation Biological Effects Secondary Cancer
DOI10.1007/s41365-017-0225-8
文献子类Article
英文摘要Image-guided radiotherapy (IGRT) provides precise positioning for the tumor target, but it may bring extra irradiation dose in the target positioning with a cone beam CT (CBCT) which has been increasingly used in IGRT. In this work, we focused on biological effects of the low-dose irradiation in IGRT, which have not been considered so far. Primary human fibroblasts cells from the lung and MRC-5 were irradiated by a CBCT. DNA double-strand breaks (c-H2AX foci) and micronucleus frequency of the irradiated samples were analyzed. Compared to the control, the c-H2AX foci yields of the samples irradiated to 16 mGy increased significantly, and the micronuclei rate of the samples irradiated for 3 days increased notably. The dose by imaging guidance device can be genotoxic to normal tissue cells, suggesting a potential risk of a secondary cancer. The effects, if confirmed by clinical studies, should be considered prudentially in designing IGRT treatment plans for the radiosensitive population, especially for children.
WOS关键词CONE-BEAM CT ; RADIATION-THERAPY ; CANCER
WOS研究方向Nuclear Science & Technology ; Physics
语种英语
WOS记录号WOS:000402894900015
资助机构Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA03040000) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; National Natural Science Foundation(30900386) ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; Anhui Provincial Natural Science Foundation(090413095 ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; National Natural Science Foundation of Department of Education of Anhui Province(KJ2010B380) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55) ; 11040606Q55)
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/31951]  
专题合肥物质科学研究院_中国科学院核能安全技术研究所
作者单位1.Univ Sci & Technol China, Sch Nucl Sci & Technol, Hefei 30027, Peoples R China
2.Chinese Acad Sci, Inst Nucl Energy Safety Technol, Key Lab Neutron & Radiat Safety, Hefei 230031, Peoples R China
推荐引用方式
GB/T 7714		 Jin, Chu-Feng,Liu, Hui,Li, Wen-Yi,et al. Biological effects of human lung cells MRC-5 in CBCT positioning for image-guided radiotherapy[J]. NUCLEAR SCIENCE AND TECHNIQUES,2017,28(5):1-5.
APA Jin, Chu-Feng,Liu, Hui,Li, Wen-Yi,&Cao, Rui-Fen.(2017).Biological effects of human lung cells MRC-5 in CBCT positioning for image-guided radiotherapy.NUCLEAR SCIENCE AND TECHNIQUES,28(5),1-5.
MLA Jin, Chu-Feng,et al."Biological effects of human lung cells MRC-5 in CBCT positioning for image-guided radiotherapy".NUCLEAR SCIENCE AND TECHNIQUES 28.5(2017):1-5.

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。