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Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices

文献类型：期刊论文

作者Yang, Ke1,2; Peretz-Soroka, Hagit2; Wu, Jiandong2; Zhu, Ling1; Cui, Xueling3; Zhang, Michael4; Rigatto, Claudio4; Liu, Yong1; Lin, Francis2,5,6,7
刊名SCIENTIFIC REPORTS
出版日期2017-06-08
卷号7期号:无页码:1-12
DOI10.1038/s41598-017-03210-0
文献子类Article
英文摘要Neutrophil trafficking in tissues critically regulates the body's immune response. Neutrophil migration can either play a protective role in host defense or cause health problems. Fibroblast growth factor 23 (FGF23) is a known biomarker for chronic kidney disease (CKD) and was recently shown to impair neutrophil arrest on endothelium and transendothelial migration. In the present study, we further examined the effect of FGF23 on human blood neutrophil chemotaxis using two new microfluidic devices. Our results showed that chemotaxis of FGF23 pre-treated neutrophils to a fMLP gradient, in the presence or absence of a uniform FGF23 background, is quantitatively lower compared to the control cells. This effect is accompanied with a stronger drifting of FGF23 pre-treated cells along the flow. However, without the FGF23 pre-treatment, the FGF23 background only reduces chemotaxis of transmigrated cells through the thin barrier channel to the fMLP gradient. The effect of FGF23 on neutrophil migration and the correlation between multiple cell migration parameters are further revealed by chemotactic entropy and principle component analysis. Collectively, these results revealed the effect of FGF23 on weakening neutrophil chemotaxis, which shed light on FGF23 mediated neutrophil migration with direct disease relevance such as CKD.
WOS关键词CHRONIC KIDNEY-DISEASE ; FGF23 ; MORTALITY ; MIGRATION ; ACTIVATION ; INFECTION ; DIALYSIS ; IMMUNITY ; SEPSIS ; INNATE
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000402865200012
资助机构Natural Sciences and Engineering Research Council of Canada (NSERC) ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; Canadian Institutes of Health Research (CIHR) ; Canadian Institutes of Health Research (CIHR) ; Canadian Institutes of Health Research (CIHR) ; Canadian Institutes of Health Research (CIHR) ; CMC Microsystems ; CMC Microsystems ; CMC Microsystems ; CMC Microsystems ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; University of Manitoba ; University of Manitoba ; University of Manitoba ; University of Manitoba ; NSERC ; NSERC ; NSERC ; NSERC ; Mitacs ; Mitacs ; Mitacs ; Mitacs ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; Canadian Institutes of Health Research (CIHR) ; Canadian Institutes of Health Research (CIHR) ; Canadian Institutes of Health Research (CIHR) ; Canadian Institutes of Health Research (CIHR) ; CMC Microsystems ; CMC Microsystems ; CMC Microsystems ; CMC Microsystems ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; University of Manitoba ; University of Manitoba ; University of Manitoba ; University of Manitoba ; NSERC ; NSERC ; NSERC ; NSERC ; Mitacs ; Mitacs ; Mitacs ; Mitacs
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/31920]  
专题合肥物质科学研究院_应用技术研究所
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Appl Technol, Hefei, Anhui, Peoples R China
2.Univ Manitoba, Dept Phys & Astron, Winnipeg, MB, Canada
3.Jilin Univ, Dept Genet, Changchun, Jilin Sheng, Peoples R China
4.Seven Oaks Gen Hosp, Winnipeg, MB, Canada
5.Univ Manitoba, Dept Biosyst Engn, Winnipeg, MB, Canada
6.Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada
7.Univ Manitoba, Dept Biol Sci, Winnipeg, MB, Canada
推荐引用方式
GB/T 7714		 Yang, Ke,Peretz-Soroka, Hagit,Wu, Jiandong,et al. Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices[J]. SCIENTIFIC REPORTS,2017,7(无):1-12.
APA Yang, Ke.,Peretz-Soroka, Hagit.,Wu, Jiandong.,Zhu, Ling.,Cui, Xueling.,...&Lin, Francis.(2017).Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices.SCIENTIFIC REPORTS,7(无),1-12.
MLA Yang, Ke,et al."Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices".SCIENTIFIC REPORTS 7.无(2017):1-12.

入库方式： OAI收割

来源：合肥物质科学研究院

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