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The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction

文献类型：期刊论文

作者Xie, Dongxue1,2; Liu, Zhonghui3; Wu, Jiandong2; Feng, Wenfang1; Yang, Ke2,4; Deng, Jixian5; Tian, Ganghong5; Santos, Susy6; Cui, Xueling1,2; Lin, Francis2
刊名EXPERIMENTAL CELL RESEARCH
出版日期2017-08-01
卷号357期号:1页码:107-115
关键词Activin a Breast Cancer Cells Neutrophils Migration Microfluidic Device
DOI10.1016/j.yexcr.2017.05.003
文献子类Article
英文摘要Activin A belongs to the superfamily of transforming growth factor beta (TGF beta) and is a critical regulatory cytokine in breast cancer and inflammation. However, the role of activin A in migration of breast cancer cells and immune cells was not well characterized. Here, a microfluidic device was used to examine the effect of activin A on the migration of human breast cancer cell line MDA-MB-231 cells and human blood neutrophils as well as their migratory interaction. We found that activin A promoted the basal migration but impaired epidermal growth factor (EGF)-induced migration of breast cancer cells. By contrast, activin A reduced neutrophil chemotaxis and transendothelial migration to N-Formyl-Met-Leu-Phe (fMLP). Finally, activin A promoted neutrophil chemotaxis to the supernatant from breast cancer cell culture. Collectively, our study revealed the different roles of activin A in regulating the migration of breast cancer cells and neutrophils and their migratory interaction. These findings suggested the potential of activin A as a therapeutic target for inflammation and breast cancers.
WOS关键词TRANSENDOTHELIAL MIGRATION ; CHEMOTAXIS ; INVASION ; MICROFLUIDICS ; INFLAMMATION ; FOLLISTATIN ; PROGRESSION ; PHENOTYPE ; ROLES ; FLUID
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000404320700013
资助机构National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; University of Manitoba ; University of Manitoba ; University of Manitoba ; University of Manitoba ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Basic Research Program of China ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; Winnipeg Rh Institute Foundation ; University of Manitoba ; University of Manitoba ; University of Manitoba ; University of Manitoba
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/31976]  
专题合肥物质科学研究院_应用技术研究所
作者单位1.Jilin Univ, Coll Basic Med Sci, Dept Genet, Changchun 130021, Peoples R China
2.Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada
3.Jilin Univ, Coll Basic Med Sci, Dept Immunol, Changchun 130021, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Appl Technol, Hefei, Anhui, Peoples R China
5.CNR, Winnipeg, MB R3B 1Y6, Canada
6.Victoria Gen Hosp & River Hts Ft Garry Community, Winnipeg, MB, Canada
推荐引用方式
GB/T 7714		 Xie, Dongxue,Liu, Zhonghui,Wu, Jiandong,et al. The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction[J]. EXPERIMENTAL CELL RESEARCH,2017,357(1):107-115.
APA Xie, Dongxue.,Liu, Zhonghui.,Wu, Jiandong.,Feng, Wenfang.,Yang, Ke.,...&Lin, Francis.(2017).The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction.EXPERIMENTAL CELL RESEARCH,357(1),107-115.
MLA Xie, Dongxue,et al."The effects of activin A on the migiation of human breast cancer cells and neutrophils and their migratory interaction".EXPERIMENTAL CELL RESEARCH 357.1(2017):107-115.

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来源：合肥物质科学研究院

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