The high-speed camera is an imaging device that records a particular transient state or all of the high-speed processes. It can accurately record the transient process of the high-speed target in real time and thus allow us to achieve the purpose of analysis of high-speed process through the slow motion playback. So the high-speed camera becomes an important tool for the study of the transient phenomena. This paper presents the development of a high-speed imaging system, which was build based upon a CMOS (Complementary Metal Oxide Semiconductor) image sensor and a high density FPGA (Field Programmable Gate Array) and USB 3.0 (Universal Serial Bus 3.0). In this paper, the design methodology and the electronics system architecture are briefly discussed. Besides, the designs and implements are particularly depicted. Finally the experimental verification shows the correlated results. The system has the advantage of high frame rate, high resolution, high performance and flexibility.