In experimental studies of inertial confinement fusion (ICF). scientific grade charge-coupled device (CCD) cameras are widely used for temporal and spatial investigations of the physical processes that occur during such experiments, such as shock waves. The performance of such a camera is directly related to its accuracy and credibility of measurement, so it is important to calibrate the photoelectric response characteristics of a scientific grade CCD camera before using it. The traditional system and process used for calibration is complex, involving measurement errors that can adversely affect the accuracy and confidence of calibration. This paper proposes a new method that relies on wedge interference is used images captured by the CCD camera to be calibrated and the calculated laser intensity distribution due to interference to obtain the photoelectric response characteristics of the camera via data processing. This method not only ensures realistic and reliable calibration results but also is simple and fast, providing a basis for obtaining accurate data in ICF experiments.