Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities
文献类型：期刊论文
| 作者 | Liu, SW; Luo, XW; Yang, J; Chen, FM; Lin, XP; Chen, CM; Zhou, XF; Liu, YH |
| 刊名 | FRONTIERS IN CHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 6页码:-282 |
| 通讯作者 | xfzhou@scsio.ac.cn ; liusw@smu.edu.cn ; yonghongliu@scsio.ac.cn |
| 英文摘要 | Influenza A virus (IAV) is a severe worldwide threat to public health and economic development due to its high morbidity and mortality. Marine-derived fungi have been evidenced as a prolific source for the discovery of pharmacologically-active lead compounds. During the course of our search for novel bioactive substances from marine microorganisms, six new polyketides, including two octaketides (1-2), one chromone derivative (13), two highly substituted phthalides (17-18), and one alpha-pyrone derivative (21) along with 22 known congeners were isolated from a mangrove-associated fungus Diaporthe sp. SCSIO 41011. Their structures were determined by spectroscopic analysis and by comparison with literature data. And the absolute configurations were established according to the specific rotation or electron circular dichroism method. Antiviral evaluation results revealed that compounds 14, 15, 26, and 5-chloroisorotiorin displayed significant anti-IAV activities against three influenza A virus subtypes, including A/Puerto Rico/8/34 H274Y (H1N1), A/FM-1/1/47 (H1N1), and A/Aichi/2/68 (H3N2), with IC50 values in the range of 2.52-39.97 mu M. The preliminary structure-activity relationships (SARs) are also discussed. These findings expand the chemical and bioactive diversity of polyketides derived from the genus Diaporthe, and also provide a basis for further development and utilization of chromone, xanthone, and chloroazaphilone derivatives as source of potential anti-viral chemotherapy agents. |
| 学科主题 | Chemistry |
| 关键词[WOS] | Diaporthe sp ; polyketides ; cytosporones ; phthalides ; anti-influenza A virus |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16922]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, SW,Luo, XW,Yang, J,et al. Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities[J]. FRONTIERS IN CHEMISTRY,2018,6:-282. |
| APA | Liu, SW.,Luo, XW.,Yang, J.,Chen, FM.,Lin, XP.,...&Liu, YH.(2018).Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities.FRONTIERS IN CHEMISTRY,6,-282. |
| MLA | Liu, SW,et al."Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp SCSIO 41011 With Their Anti-influenza A Virus Activities".FRONTIERS IN CHEMISTRY 6(2018):-282. |
入库方式： OAI收割
来源：南海海洋研究所
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