Activated production of silent metabolites from marine-derived fungus Penicillium citrinum
文献类型：期刊论文
| 作者 | Chen, GT; Gu, YQ; Ding, PY; Liang, ZP; Song, Y; Liu, YH; Li, JL |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2018 |
| 卷号 | 127页码:207-211 |
| 通讯作者 | guangtong_chen@ntu.edu.cn ; jianlinli1980@163.com |
| 英文摘要 | As an attempt to utilize of rare earth elements as a novel method to activate the silent genes in fungus, the marine-derived fungus Penicillitan citrinum was cultured under ordinary laboratory fermentation conditions in the presence of scandium chloride (ScCl3, 50 mu M), and chemical investigation led to the isolation and characterization of three new peptide derivatives (1-3), along with four known pyrrolidine alkaloids (4-7). Those structures were elucidated by spectroscopic data interpretation, as well as chemical reactions. Comparative metabolic profiling of the culture extracts (with/without scandium chloride) indicated that compounds 1-3 scarcely detected in the absence of ScCl3. In addition, the antibacterial and cytotoxic activities of all isolated products were evaluated. |
| 学科主题 | Pharmacology & Pharmacy |
| 关键词[WOS] | Penicillium citrinum ; Scandium chloride treated cultures ; Activated production of silent metabolites ; Antibacterial activity ; Cytotoxic activity |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16934]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, GT,Gu, YQ,Ding, PY,et al. Activated production of silent metabolites from marine-derived fungus Penicillium citrinum[J]. FITOTERAPIA,2018,127:207-211. |
| APA | Chen, GT.,Gu, YQ.,Ding, PY.,Liang, ZP.,Song, Y.,...&Li, JL.(2018).Activated production of silent metabolites from marine-derived fungus Penicillium citrinum.FITOTERAPIA,127,207-211. |
| MLA | Chen, GT,et al."Activated production of silent metabolites from marine-derived fungus Penicillium citrinum".FITOTERAPIA 127(2018):207-211. |
入库方式： OAI收割
来源：南海海洋研究所
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