New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025
文献类型：期刊论文
| 作者 | Liang, X; Huang, ZH; Nong, XH; Qi, SH |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2018 |
| 卷号 | 74期号:21页码:2620-2626 |
| 通讯作者 | shuhuaqi@scsio.ac.cn |
| 英文摘要 | Eight new tetramic acid derivatives, cladosporiumins A-H (1-8) were isolated from a culture broth of Cladosporium sp. SCSIO z0025 derived from the deep-sea sediment collected from Okinawa Trough. Their structures were elucidated by extensive spectroscopic data analysis. Compounds 1-3 were unique 3acyltetramic acids with a hexyl enic alcohol side chain and a six-membered lactone ring substituted at C-3 of the 2, 4-pyrrolidinedione skeleton. The absolute configurations of chiral carbons of the 2, 4pyrrolidinedione unit in 1-4 and 7 were established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. And the absolute configurations of chiral carbons of the sixmembered lactone ring in 1-3 were established by density functional theory calculation of their C-13 NMR chemical shifts. In addition, all the compounds were tested for cytotoxic, antibacterial, anti-biofilm, and AchE inhibitory activities. (C) 2018 Elsevier Ltd. All(C)rights reserved. |
| 学科主题 | Chemistry |
| 关键词[WOS] | Deep-sea fungus ; Cladosporium sp SCSIO Z0025 ; Tetramic acid derivatives ; Quantum chemical calculations |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16946]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Liang, X,Huang, ZH,Nong, XH,et al. New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025[J]. TETRAHEDRON,2018,74(21):2620-2626. |
| APA | Liang, X,Huang, ZH,Nong, XH,&Qi, SH.(2018).New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025.TETRAHEDRON,74(21),2620-2626. |
| MLA | Liang, X,et al."New tetramic acid derivatives from the deep-sea-derived fungus Cladosporium sp SCSIO z0025".TETRAHEDRON 74.21(2018):2620-2626. |
入库方式： OAI收割
来源：南海海洋研究所
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