Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant
文献类型：期刊论文
| 作者 | Zhang, HB; Tian, XX; Pu, XH; Zhang, QB; Zhang, CS; Zhang, WJ |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2018 |
| 卷号 | 81期号:5页码:1219-1224 |
| 通讯作者 | czhang@scsio.ac.cn |
| 英文摘要 | Tiacumicin B (1, also known as fidaxomicin or difimicin) is a marketed drug for the treatment of Clostridium difficile infections. The biosynthetic pathway of 1 has been studied in Dactylosporangium aurantiacum subsp. hamdenensis NRRL 18085 and has enabled the identification of TiaM as a tailoring dihalogenase. Herein we report the isolation, structure elucidation, and bioactivity evaluation of 14 tiacumicin congeners (including 11 new ones) from the tiaM-inactivated mutant. A new tiacumicin congener, 3, with a propyl group at C-7 ''' of the aromatic ring was found to exhibit improved antibacterial activity. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16956]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, HB,Tian, XX,Pu, XH,et al. Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(5):1219-1224. |
| APA | Zhang, HB,Tian, XX,Pu, XH,Zhang, QB,Zhang, CS,&Zhang, WJ.(2018).Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant.JOURNAL OF NATURAL PRODUCTS,81(5),1219-1224. |
| MLA | Zhang, HB,et al."Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant".JOURNAL OF NATURAL PRODUCTS 81.5(2018):1219-1224. |
入库方式： OAI收割
来源：南海海洋研究所
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