The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin
文献类型：期刊论文
| 作者 | Huang, Y; Deng, YC; Kang, DD; Shi, J; Zhou, WQ; Sun, AJ; Ju, JH; Zhu, XC; Shen, B; Duan, YW |
| 刊名 | MEDCHEMCOMM
 |
| 出版日期 | 2018 |
| 卷号 | 9期号:5页码:789-794 |
| 通讯作者 | shenb@scripps.edu ; ywduan66@yahoo.com ; jonghuang@csu.edu.cn |
| 英文摘要 | A dozen oxime, hydrazine and hydrazide derivatives of platensimycin (PTM) analogues were synthesized, some of which showed strong antibacterial activities and were shown to be stable under the bioassay conditions. Docking analysis revealed that they have certain new interactions with beta-ketoacyl-[acyl carrier protein] synthase II (FabF), suggesting that Schiff base formation on its terpene scaffold is an effective strategy to diversify PTM structure. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16958]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Huang, Y,Deng, YC,Kang, DD,et al. The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin[J]. MEDCHEMCOMM,2018,9(5):789-794. |
| APA | Huang, Y.,Deng, YC.,Kang, DD.,Shi, J.,Zhou, WQ.,...&Duan, YW.(2018).The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin.MEDCHEMCOMM,9(5),789-794. |
| MLA | Huang, Y,et al."The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin".MEDCHEMCOMM 9.5(2018):789-794. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。