Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89
文献类型：期刊论文
| 作者 | Sun, JB; Shao, JL; Sun, CL; Song, YX; Li, QL; Lu, LC; Hu, YF; Gui, C; Zhang, H; Ju, JH |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 26期号:8页码:1488-1494 |
| 通讯作者 | huazhang@gdmu.edu.cn ; jju@scsio.ac.cn |
| 英文摘要 | Borrelidin A (1) is produced by several species of Streptomyces and within its bioactive scaffold, the vinylic nitrile moiety is essential for activity. We report herein newly discovered members of the borrelidin family, borrelidin F (2), borrelidin G (3), borrelidin H (4) and borrelidin I (5); all were isolated from Streptomyces rochei SCSIO ZJ89 originating from a mangrove-derived sediment sample. These structurally diverse metabolites enabled a number of new structure-activity relationships (SARs) to be identified, especially with respect to the different configurations at the C11-OH and C12-C15 double bonds for which the absolute configurations were determined using spectroscopic methods. Importantly, borrelidin H (4) was found to have a therapeutic window superior to that of borrelidin A (1) in vitro and could inhibit migration of cancer cells. (C) 2018 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry |
| 关键词[WOS] | Borrelidin ; Streptomyces ; Cancer ; Cytotoxic activity ; Migration |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16961]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, JB,Shao, JL,Sun, CL,et al. Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2018,26(8):1488-1494. |
| APA | Sun, JB.,Shao, JL.,Sun, CL.,Song, YX.,Li, QL.,...&Ju, JH.(2018).Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89.BIOORGANIC & MEDICINAL CHEMISTRY,26(8),1488-1494. |
| MLA | Sun, JB,et al."Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89".BIOORGANIC & MEDICINAL CHEMISTRY 26.8(2018):1488-1494. |
入库方式： OAI收割
来源：南海海洋研究所
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