Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011
文献类型：期刊论文
| 作者 | Luo, XW; Lin, XP; Tao, HM; Wang, JF; Li, JY; Yang, B; Zhou, XF; Liu, YH |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2018 |
| 卷号 | 81期号:4页码:934-941 |
| 通讯作者 | xfzhou@scsio.ac.cn ; yonghongliup@scsio.ac.cn |
| 英文摘要 | Six new highly oxygenated chloroazaphilone derivatives, isochromophilones A-F (1-6), were obtained from the mangrove-derived fungus Diaporthe sp. SCSIO 41011, together with six known analogues (7-12). The structures of 1-6 including absolute configurations were determined by detailed NMR, MS spectroscopic analyses, and electronic circular dichroism spectra. Compounds 1 and 2 represent the first reported azaphilones lacking a carbonyl group at C-6. Compound 8 exhibited cytotoxic activities against three renal carcinoma cell lines, ACHN, OS-RC-2, and 786-O cells, with IC50 values ranging from 3.0 to 4.4 mu M, and 4 showed activity against 786-O cells with an ICso of 8.9 mu M. Further studies indicated that 4 induced apoptosis in 786-O cells in a dose- and time-dependent manner. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16971]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Luo, XW,Lin, XP,Tao, HM,et al. Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(4):934-941. |
| APA | Luo, XW.,Lin, XP.,Tao, HM.,Wang, JF.,Li, JY.,...&Liu, YH.(2018).Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011.JOURNAL OF NATURAL PRODUCTS,81(4),934-941. |
| MLA | Luo, XW,et al."Isochromophilones A-F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp SCSIO 41011".JOURNAL OF NATURAL PRODUCTS 81.4(2018):934-941. |
入库方式： OAI收割
来源：南海海洋研究所
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