Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452
文献类型：期刊论文
| 作者 | Zhong, WM; Wang, JF; Shi, XF; Wei, XY; Chen, YC; Zeng, Q; Xiang, Y; Chen, XY; Tian, XP; Xiao, ZH |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:4页码:-136 |
| 通讯作者 | wmzhong@scsio.ac.cn ; wangjunfeng@scsio.ac.cn ; shixuefeng@scsio.ac.cn ; wxy@scbg.ac.cn ; chenyc@gdim.cn ; 18489875310@163.com ; xy920412@sina.cn ; xychen1994@gmail.com ; xinpengtian@scsio.ac.cn ; xzh@scsio.ac.cn ; wmzhang@gdim.cn ; wangfazuo@scsio.ac.cn ; zhsimd@scsio.ac.cn |
| 英文摘要 | Three new prenylated indole 2,5-diketopiperazine alkaloids (1-3) with nine known ones (5-13), one new indole alkaloid (4), and one new bis-benzyl pyrimidine derivative (14) were isolated and characterized from the marine-derived fungus Eurotium sp. SCSIO F452. 1 and 2, occurring as a pair of diastereomers, both presented a hexahydropyrrolo[2,3-b] indole skeleton. Their chemical structures, including absolute configurations, were elucidated by 1D and 2D NMR, HRESIMS, quantum chemical calculations of electronic circular dichroism, and single crystal X-ray diffraction experiments. Most isolated compounds were screened for antioxidative potency. Compounds 3, 5, 6, 7, 9, 10, and 12 showed significant radical scavenging activities against DPPH with IC50 values of 13, 19, 4, 3, 24, 13, and 18 mu M, respectively. Five new compounds were evaluated for cytotoxic activities. |
| 学科主题 | Pharmacology & Pharmacy |
| 关键词[WOS] | prenylated indole alkaloid ; benzyl pyrimidine ; antioxidative and cytotoxic activities ; marine fungi |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16972]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhong, WM,Wang, JF,Shi, XF,et al. Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452[J]. MARINE DRUGS,2018,16(4):-136. |
| APA | Zhong, WM.,Wang, JF.,Shi, XF.,Wei, XY.,Chen, YC.,...&Zhang, S.(2018).Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452.MARINE DRUGS,16(4),-136. |
| MLA | Zhong, WM,et al."Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452".MARINE DRUGS 16.4(2018):-136. |
入库方式： OAI收割
来源：南海海洋研究所
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