New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001
文献类型：期刊论文
| 作者 | Wang, JF; Zhou, LM; Chen, ST; Yang, B; Liao, SR; Kong, FD; Lin, XP; Wang, FZ; Zhou, XF; Liu, YH |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2018 |
| 卷号 | 125页码:49-54 |
| 英文摘要 | Seven new compounds, including four new chlorinated diphenyl ethers, namely chrysines A-D (1-4), one new dichlorinated xanthone, chrysoxanthone (5), dichloroorcinol (6), and one new benzeneacetic acid derivative, 3-isopentyl-4-hydroxy phenylacetic acid methyl ester (7), along with fourteen known compounds (8-21), were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures were determined by extensive spectroscopic methods and X-ray single-crystal diffraction analysis. All of the isolated compounds (1 - 21) were evaluated for their a-glucosidase inhibitory activity using PNPG method. Among them, nine compounds (2, 3, 5, 6, 8, 9, 13, 17, and 18) exhibited inhibitory activity against alpha-glucosidase with IC50 values of 0.35, 0.20, 0.04, 0.16, 0.15, 0.09, 0.14, 0.14, and 0.12 mM, respectively (IC50 0.28 mM for the positive control acarbose). |
| 学科主题 | Pharmacology & Pharmacy |
| WOS关键词 | Penicillium chrysogenum ; Diphenyl ether ; Xanthone ; alpha-Glucosidase inhibitory activity |
| 资助项目 | LMB |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/16995]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | wangjunfeng@scsio.ac.cn; yonghongliu@scsio.ac.cn |
| 推荐引用方式 GB/T 7714 | Wang, JF,Zhou, LM,Chen, ST,et al. New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001[J]. FITOTERAPIA,2018,125:49-54. |
| APA | Wang, JF.,Zhou, LM.,Chen, ST.,Yang, B.,Liao, SR.,...&yonghongliu@scsio.ac.cn.(2018).New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001.FITOTERAPIA,125,49-54. |
| MLA | Wang, JF,et al."New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001".FITOTERAPIA 125(2018):49-54. |
入库方式： OAI收割
来源：南海海洋研究所
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