Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32
文献类型：期刊论文
| 作者 | Lai, ZZ; Yu, JC; Ling, HP; Song, YX; Yuan, J; Ju, JH; Tao, YW; Huang, HB |
| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2018 |
| 卷号 | 84期号:3页码:201-207 |
| 通讯作者 | yywentao@aliyun.com ; huanghb@scsio.ac.cn |
| 英文摘要 | Three new angucycline glycosides, designated grincamycin I ( 1 ), J ( 2 ), and K ( 3 ), together with the known congener A-7884 ( 4 ), were isolated from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2 and 4 exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC (50) values ranging from 0.4 to 6.9 mu M. In addition, A-7884 ( 4 ) demonstrated antimicrobial activity against Micrococcus luteus with an MIC value of 1.95 mu g/mL. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine |
| 关键词[WOS] | angucycline glycoside ; naphthacenequinone ; cytotoxicity ; marine actinomycete ; Streptomyces lusitanus ; Streptomycetaceae |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17011]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Lai, ZZ,Yu, JC,Ling, HP,et al. Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32[J]. PLANTA MEDICA,2018,84(3):201-207. |
| APA | Lai, ZZ.,Yu, JC.,Ling, HP.,Song, YX.,Yuan, J.,...&Huang, HB.(2018).Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32.PLANTA MEDICA,84(3),201-207. |
| MLA | Lai, ZZ,et al."Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32".PLANTA MEDICA 84.3(2018):201-207. |
入库方式： OAI收割
来源：南海海洋研究所
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