Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations
文献类型：期刊论文
| 作者 | Sun, CL; Zhang, CY; Qin, XJ; Wei, XY; Liu, Q; Li, QL; Ju, JH |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2018 |
| 卷号 | 74期号:1页码:199-203 |
| 通讯作者 | jju@scsio.ac.cn |
| 英文摘要 | Naphthoquinone macrolides have attracted considerable synthetic interest due to their unique scaffolds, but there was no completion of total synthesis reported. In this study, genome mining and genetic manipulations were applied to stimulate the production of naphthoquinone macrolides from the deep-sea actinomycete Streptomyces olivaceus SCSIO T05; as a result, new metabolites olimycins A and B (1, 2) were isolated. The structures were elucidated on the basis of extensive spectroscopic data and X-ray single crystal diffraction studies. The results of these efforts enabled rectification of a key structural error made during previous efforts to characterize naphthoquinone macrolides. (C) 2017 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry |
| 关键词[WOS] | Genome mining ; Naphthoquinone macrolides ; Absolute configuration ; Structure rectification |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17018]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, CL,Zhang, CY,Qin, XJ,et al. Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations[J]. TETRAHEDRON,2018,74(1):199-203. |
| APA | Sun, CL.,Zhang, CY.,Qin, XJ.,Wei, XY.,Liu, Q.,...&Ju, JH.(2018).Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations.TETRAHEDRON,74(1),199-203. |
| MLA | Sun, CL,et al."Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations".TETRAHEDRON 74.1(2018):199-203. |
入库方式： OAI收割
来源：南海海洋研究所
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