Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity
文献类型：期刊论文
| 作者 | Li, Qing1 ; Qiu, Lishushi2; Tan, Wenqiang1,3; Gu, Guodong4; Guo, Zhanyong1; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China)
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:67页码:42225-42232 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c7ra08244d |
| 产权排序 | 第1完成单位 |
| 文献子类 | Article |
| 英文摘要 | A new class of inulin derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. After the chemical modification, all the inulin derivatives showed good solubility in water, and exhibited excellent bioactivity compared to inulin. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, the scavenging activity of 1,2,3-triazolium inulin derivatives (5a-5d) (IC50 0.21-0.29 mg mL(-1)) was found to be higher than that of inulin derivatives (4a-4d) (IC50 0.58-0.95 mg mL(-1)) and inulin. 5a-5d (IC50 < 0.01 mg mL(-1)) also exhibited stronger inhibitory activity against superoxide anion formation than 4a-4d (IC50 0.02-0.09 m g mL(-1)) and Vitamin C (IC50 0.02 mg mL(-1)). In the antifungal assays, 5a-5d also inhibited the growth of tested phytopathogens more effectively with inhibitory indices of 43.10-82.56% at 1.0 mg mL(-1), compared with 4a-4d and inulin. Based on these data, it is reasonable to propose that the introduction of 1,2,3-triazolium group through chemical modification is significant to enhance the free radical-scavenging activity and antifungal activity of inulin. |
| URL标识 | 查看原文 |
| WOS关键词 | ANTIBACTERIAL ACTIVITY ; CHITOSAN DERIVATIVES ; ANTIOXIDANT ; 1,2,4-TRIAZOLES ; INHIBITORS ; DESIGN ; POLYSACCHARIDES ; SALTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000409147500033 |
| 资助机构 | National Natural Science Foundation of China(41576156) ; Shandong Province Science and Technology Development Plan(2015GSF121045, ZR2017BD015) ; Yantai Science and Technology Development Plan(2015ZH078) ; Technology Research Funds Projects of Ocean(2015050223) |
| 源URL | [http://ir.yic.ac.cn/handle/133337/23425]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, Zhanyong; Guo, Zhanyong(Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China) |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China 2.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 推荐引用方式 GB/T 7714 | Li, Qing,Qiu, Lishushi,Tan, Wenqiang,et al. Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity[J]. RSC ADVANCES,2017,7(67):42225-42232. |
| APA | Li, Qing,Qiu, Lishushi,Tan, Wenqiang,Gu, Guodong,Guo, Zhanyong,&Guo, Zhanyong.(2017).Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity.RSC ADVANCES,7(67),42225-42232. |
| MLA | Li, Qing,et al."Novel 1,2,3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity".RSC ADVANCES 7.67(2017):42225-42232. |
入库方式： OAI收割
来源：烟台海岸带研究所
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