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  2. 烟台海岸带研究所
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  4. 海岸带生物学与生物资源利用重点实验室
  5. 海岸带生物学与生物资源利用所重点实验室
Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes

文献类型：期刊论文

作者Leger, Michelle M.1,11; Kolisko, Martin1,12; Kamikawa, Ryoma2; Stairs, Courtney W.1,6; Kume, Keitaro3; Cepicka, Ivan4; Silberman, Jeffrey D.5; Andersson, Jan O.6; Xu, Feifei6; Yabuki, Akinori7
刊名NATURE ECOLOGY & EVOLUTION
出版日期2017-04-01
卷号1期号:4
ISSN号2397-334X
DOI10.1038/s41559-017-0092
文献子类Article
英文摘要Many anaerobic microbial parasites possess highly modified mitochondria known as mitochondrion-related organelles (MROs). The best-studied of these are the hydrogenosomes of Trichomonas vaginalis and Spironucleus salmonicida, which produce ATP anaerobically through substrate-level phosphorylation with concomitant hydrogen production; and the mitosomes of Giardia intestinalis, which are functionally reduced and lack any role in ATP production. Howewer, to understand the metabolic specializations that these MROs underwent in adaptation to parasitism, data from their free-living relatives are needed. Here, we present a large-scale comparative transcriptomic study of MROs across a major eukaryotic group, Metamonada, examining lineage-specific gain and loss of metabolic functions in the MROs of Trichomonas, Giardia, Spironucleus and their free-living relatives. Our analyses uncover a complex history of ATP production machinery in diplomonads such as Giardia, and their closest relative, Dysnectes; and a correlation between the glycine cleavage machinery and lifestyles. Our data further suggest the existence of a previously undescribed biochemical class of MRO that generates hydrogen but is incapable of ATP synthesis.
WOS关键词GLYCINE DECARBOXYLASE COMPLEX ; ACETYL-COA SYNTHETASE ; TRITRICHOMONAS-FETUS ; PYRUVATE METABOLISM ; CLEAVAGE SYSTEM ; PROTEIN IMPORT ; MITOCHONDRIAL ; EVOLUTION ; VAGINALIS ; PHYLOGENIES
WOS研究方向Environmental Sciences & Ecology ; Evolutionary Biology
语种英语
WOS记录号WOS:000417171500014
出版者NATURE PUBLISHING GROUP
资助机构Canadian Institutes of Health Research(MOP-142349) ; JSPS Strategic Young Researcher Overseas Visits Program ; NSERC Grant(298366-2009) ; Czech Science Foundation(GA14-14105S) ; Japan Society for the Promotion of Science (JSPS)(15H05606, 15K14591, 23117005, 15H05231, 23117006)
源URL[http://ir.yic.ac.cn/handle/133337/24047]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Hashimoto, Tetsuo; Roger, Andrew J.
作者单位1.Dalhousie Univ, Dept Biochem & Mol Biol, 5850 Coll St,POB 15000, Halifax, NS B3H 4R2, Canada
2.Kyoto Univ, Grad Sch Global Environm Studies, Grad Sch Human & Environm Studies, Sakyo Ku, Yoshida Honmachi, Kyoto 6068501, Japan
3.Univ Tsukuba, Ctr Computat Sci, Grad Sch Life & Environm Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058572, Japan
4.Charles Univ Prague, Fac Sci, Dept Zool, Vinicna 7, CR-12844 Prague 2, Czech Republic
5.Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA
6.Uppsala Univ, Dept Cell & Mol Biol, Box 596, S-75124 Uppsala, Sweden
7.Japan Agcy Marine Earth Sci & Technol JAMSTEC, 2-15 Natsushima Cho, Yokosuka, Kanagawa 2370061, Japan
8.Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Shandong, Peoples R China
9.Univ Tsukuba, Ctr Computat Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan
10.Dalhousie Univ, Dept Biol, 1355 Oxford St,POB 15000, Halifax, NS B3H 4R2, Canada
推荐引用方式
GB/T 7714		 Leger, Michelle M.,Kolisko, Martin,Kamikawa, Ryoma,et al. Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes[J]. NATURE ECOLOGY & EVOLUTION,2017,1(4).
APA Leger, Michelle M..,Kolisko, Martin.,Kamikawa, Ryoma.,Stairs, Courtney W..,Kume, Keitaro.,...&Roger, Andrew J..(2017).Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes.NATURE ECOLOGY & EVOLUTION,1(4).
MLA Leger, Michelle M.,et al."Organelles that illuminate the origins of Trichomonas hydrogenosomes and Giardia mitosomes".NATURE ECOLOGY & EVOLUTION 1.4(2017).

入库方式： OAI收割

来源：烟台海岸带研究所

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