Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase
文献类型：期刊论文
| 作者 | Douglas J. MacNeil ; James L. Occi ; Keith M. Gewain ; Tanya MacNeil ; Patrice H. Gibbons ; Carolyn L. Ruby and Susan J. Danis |
| 刊名 | Gene
 |
| 出版日期 | 1992 |
| 卷号 | 115期号:1,2页码:119-125 |
| 关键词 | Erythromycin Macrolide Recombinant Dna Fermentation |
| ISSN号 | 0378-1119 |
| 英文摘要 | The avermectin (Av) polyketide synthase (PKS) and erythromycin (Er) PKS are encoded by modular repeats of DNA, but the genetic organization of the modules encoding Av PKS is more complex than Er PKS. Sequencing of several related DNA fragments from Streptomyces avermitilis that are part of the Av biosynthetic gene cluster, revealed that they encode parts of large multifunctional PKS proteins. The Av PKS proteins show strong similarity to each other, as well as similarity to Er PKS proteins [Donadio et al., Science 252 (1991) 675–679] and fatty acid synthases. Partial DNA sequencing of the 65-kb region containing all the related sequence elements in the avr genes provides evidence for twelve modular repeats encoding FAS-like domains. The genes encoding the Av PKS are organized as two sets of six modular repeats which are convergently transcribed. |
| 公开日期 | 2011-01-07 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/3154]  |
| 专题 | 烟台海岸带研究所_科研共享资源 |
| 推荐引用方式 GB/T 7714 | Douglas J. MacNeil,James L. Occi,Keith M. Gewain,et al. Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase[J]. Gene,1992,115(1,2):119-125. |
| APA | Douglas J. MacNeil,James L. Occi,Keith M. Gewain,Tanya MacNeil,Patrice H. Gibbons,&Carolyn L. Ruby and Susan J. Danis.(1992).Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase.Gene,115(1,2),119-125. |
| MLA | Douglas J. MacNeil,et al."Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase".Gene 115.1,2(1992):119-125. |
入库方式： OAI收割
来源：烟台海岸带研究所
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