中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

文献类型:期刊论文

作者Douglas J. MacNeil ; James L. Occi ; Keith M. Gewain ; Tanya MacNeil ; Patrice H. Gibbons ; Carolyn L. Ruby and Susan J. Danis
刊名Gene
出版日期1992
卷号115期号:1,2页码:119-125
关键词Erythromycin Macrolide Recombinant Dna Fermentation
ISSN号0378-1119
英文摘要The avermectin (Av) polyketide synthase (PKS) and erythromycin (Er) PKS are encoded by modular repeats of DNA, but the genetic organization of the modules encoding Av PKS is more complex than Er PKS. Sequencing of several related DNA fragments from Streptomyces avermitilis that are part of the Av biosynthetic gene cluster, revealed that they encode parts of large multifunctional PKS proteins. The Av PKS proteins show strong similarity to each other, as well as similarity to Er PKS proteins [Donadio et al., Science 252 (1991) 675–679] and fatty acid synthases. Partial DNA sequencing of the 65-kb region containing all the related sequence elements in the avr genes provides evidence for twelve modular repeats encoding FAS-like domains. The genes encoding the Av PKS are organized as two sets of six modular repeats which are convergently transcribed.
公开日期2011-01-07
源URL[http://ir.yic.ac.cn/handle/133337/3154]  
专题烟台海岸带研究所_科研共享资源
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GB/T 7714
Douglas J. MacNeil,James L. Occi,Keith M. Gewain,et al. Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase[J]. Gene,1992,115(1,2):119-125.
APA Douglas J. MacNeil,James L. Occi,Keith M. Gewain,Tanya MacNeil,Patrice H. Gibbons,&Carolyn L. Ruby and Susan J. Danis.(1992).Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase.Gene,115(1,2),119-125.
MLA Douglas J. MacNeil,et al."Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase".Gene 115.1,2(1992):119-125.

入库方式: OAI收割

来源:烟台海岸带研究所

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