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Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice

文献类型：期刊论文

作者Zhang, Hongyu2; Yi, Yuetao1; Feng, Dawei; Wang, Yipeng; Qin, Song1
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
出版日期2011
卷号.页码:1-7
关键词Vanadyl Sulfate Insulin Sensitivity Blood-glucose In-vivo Rats Complexes Mellitus Oxidation Systems
ISSN号1741-427X
DOI10.1155/2011/691067
产权排序[Yi, Yuetao; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China; [Zhang, Hongyu] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
通讯作者Yi, YT (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China
文献子类Article
英文摘要In order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated. Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in different doses for 20 days in alloxan-induced diabetic mice. Glibenclamide was administrated as the positive control. Our results showed that low-dose group, middle-dose group, and high-dose group of VOCCA and VOCCH could significantly reduce the levels of blood glucose (P < 0.05) compared with untreated group, but not in normal mice. Besides, high-dose groups of VOCCA and VOCCH exhibited more significant hypoglycemic activities (P < 0.01). After treated with VOCCH, the oral glucose tolerance of high-dose group of VOCCH was improved compared with model control group (P < 0.05).
学科主题Integrative & Complementary Medicine
URL标识查看原文
WOS关键词VANADYL SULFATE ; INSULIN SENSITIVITY ; BLOOD-GLUCOSE ; IN-VIVO ; RATS ; COMPLEXES ; MELLITUS ; OXIDATION ; SYSTEMS
WOS研究方向Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000293527800001
资助机构Chinese Academy of Sciences[KZCX2-YW-225]; Science & Technology Development Plan of Shandong Province[2010GSF10208]; CAS/SAFEA ; Chinese Academy of Sciences KZCX2-YW-225 ; Science & Technology Development Plan of Shandong Province 2010GSF10208 ; CAS/SAFEA
公开日期2012-03-06
源URL[http://ir.yic.ac.cn/handle/133337/5353]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,et al. Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011,.:1-7.
APA Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,Wang, Yipeng,&Qin, Song.(2011).Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,.,1-7.
MLA Zhang, Hongyu,et al."Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE .(2011):1-7.

入库方式： OAI收割

来源：烟台海岸带研究所

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