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Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives

文献类型：期刊论文

作者Li, Qing1; Ren, Jianming1,2; Dong, Fang1; Feng, Yan1,2; Gu, Guodong3; Guo, Zhanyong1
刊名CARBOHYDRATE RESEARCH
出版日期2013-05-24
卷号373页码:103-107
关键词Chitosan Derivatives Antifungal Activity Thiadiazole Water Solubility
ISSN号0008-6215
DOI10.1016 / j.carres.2013.03.001
产权排序[Li, Qing; Ren, Jianming; Dong, Fang; Feng, Yan; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; [Ren, Jianming; Feng, Yan] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Gu, Guodong] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA
通讯作者Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China. qdioqdio@yahoo.com.cn
文献子类Article
英文摘要A groups of novel water soluble chitosan derivatives containing 1,3,4-thiadiazole group were synthesized including 1,3,4-thiadiazole (TPCTS), 2-methyl-1,3,4-thiadiazole (MTPCTS), and 2-phenyl-1,3,4-thiadiazole (PTPCTS). Their antifungal activity against three kinds of phytopathogens was estimated by hypha measurement in vitro, and the fungicidal assessment shows that the synthesized chitosan derivatives have excellent activity against tested fungi. Of all the synthesized chitosan derivatives, MTPCTS inhibited the growth of the tested phytopathogens most effectively with inhibitory indices of 75.3%, 82.5%, and 65.8% against Colletotrichum lagenarium (Pass) Ell. et halst, Phomopsis asparagi (Sacc.) Bubak, and Monilinia fructicola (Wint.) Honey respectively at 1.0 mg/mL. These indices are higher than those of chitosan. These data also demonstrate that the hydrophobic moiety (alkyl and phenyl) and the length of alkyl substituent in thiadiazole tend to affect the antifungal activity of chitosan derivatives. It is hypothesized that thiadiazole groups enable the synthesized chitosan to possess obviously better antifungal activity and good solubility in water. (C) 2013 Elsevier Ltd. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
URL标识查看原文
WOS关键词ANTIBACTERIAL ACTIVITY ; QUATERNIZED CHITOSAN ; MAILLARD REACTION ; SCHIFF-BASES ; IN-VITRO ; ANTICANCER ; CELLULASE
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000319040400018
资助机构National Natural Science Foundation of China [41206152]; project of National Science & Technology Pillar Program [2011 BAC02B00] ; National Natural Science Foundation of China 41206152 ; project of National Science & Technology Pillar Program 2011 BAC02B00
公开日期2013-08-14
源URL[http://ir.yic.ac.cn/handle/133337/6461]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
烟台海岸带研究所_污染过程与控制实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA
推荐引用方式
GB/T 7714		 Li, Qing,Ren, Jianming,Dong, Fang,et al. Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives[J]. CARBOHYDRATE RESEARCH,2013,373:103-107.
APA Li, Qing,Ren, Jianming,Dong, Fang,Feng, Yan,Gu, Guodong,&Guo, Zhanyong.(2013).Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives.CARBOHYDRATE RESEARCH,373,103-107.
MLA Li, Qing,et al."Synthesis and antifungal activity of thiadiazole-functionalized chitosan derivatives".CARBOHYDRATE RESEARCH 373(2013):103-107.

入库方式： OAI收割

来源：烟台海岸带研究所

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