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Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum

文献类型：期刊论文

作者Zhou, Jun1,3; Yang, Cuiyun1; Wang, Jianhua1; Sun, Pengcheng1,2; Fan, Ping2; Tian, Kai1; Liu, Sujing1; Xia, Chuanhai1
刊名ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
出版日期2013-04-01
卷号32期号:4页码:802-809
关键词Antifoulant Nonivamide Phaeodactylum Tricornutum Reactive Oxygen Species
ISSN号0730-7268
产权排序[Zhou, Jun; Yang, Cuiyun; Wang, Jianhua; Sun, Pengcheng; Tian, Kai; Liu, Sujing; Xia, Chuanhai] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing 100864, Shandong, Peoples R China; [Sun, Pengcheng; Fan, Ping] Liaoning Univ, Sch Chem, Shenyang 110036, Liaoning, Peoples R China; [Zhou, Jun] Univ Chinese Acad Sci, Beijing, Peoples R China
通讯作者Xia, CH (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing 100864, Shandong, Peoples R China. chxia@yic.ac.cn
文献子类Article
英文摘要Nonivamide, a synthetic derivate of natural capsaicin, has an effective antifouling activity. However, the poor understanding of the toxicity mechanism limits the application of nonivamide in antifouling paints. The present study investigated the inhibitory effects and toxicity mechanism of nonivamide on Phaeodactylum tricornutum. Under a 1.5x105 cells/ml of initial algal density (IAD), the effective concentration causing 50% inhibition at 4- d (4 d-EC50) value of nonivamide was 5.1mg/L. Reactive oxygen species (ROS) level was significantly increased in nonivamide-treated algae. Algal antioxidants, including catalases (CAT), peroxidases (POD), superoxide dismutases (SOD), and glutathione (GSH), were all stimulated by the ROS burst. The excessive ROS substances led to the loss of algal photosynthetic pigments and also damage to the integrity of the lipid membrane. Furthermore, ROS-related genes, including psbA, psbD, psaB, rbcL, nad1, and cob, were found to be suppressed in the chloroplasts and mitochondria of nonivamide-treated algae, and the concentration of cytoplasmic Ca2+, an important regulator of chloroplast and mitochondrion, was elevated. The present study demonstrates that nonivamide could cause peroxidative damages to P. tricornutum by inducing ROS overproduction, which may be initiated by the suppression of ROS-related genes in algal chloroplasts and mitochondria. Environ. Toxicol. Chem. 2013;32:802809. (c) 2013 SETAC; Nonivamide, a synthetic derivate of natural capsaicin, has an effective antifouling activity. However, the poor understanding of the toxicity mechanism limits the application of nonivamide in antifouling paints. The present study investigated the inhibitory effects and toxicity mechanism of nonivamide on Phaeodactylum tricornutum. Under a 1.5x105 cells/ml of initial algal density (IAD), the effective concentration causing 50% inhibition at 4- d (4 d-EC50) value of nonivamide was 5.1mg/L. Reactive oxygen species (ROS) level was significantly increased in nonivamide-treated algae. Algal antioxidants, including catalases (CAT), peroxidases (POD), superoxide dismutases (SOD), and glutathione (GSH), were all stimulated by the ROS burst. The excessive ROS substances led to the loss of algal photosynthetic pigments and also damage to the integrity of the lipid membrane. Furthermore, ROS-related genes, including psbA, psbD, psaB, rbcL, nad1, and cob, were found to be suppressed in the chloroplasts and mitochondria of nonivamide-treated algae, and the concentration of cytoplasmic Ca2+, an important regulator of chloroplast and mitochondrion, was elevated. The present study demonstrates that nonivamide could cause peroxidative damages to P. tricornutum by inducing ROS overproduction, which may be initiated by the suppression of ROS-related genes in algal chloroplasts and mitochondria. Environ. Toxicol. Chem. 2013;32:802809. (c) 2013 SETAC
学科主题Environmental Sciences ; Toxicology
URL标识查看原文
WOS关键词GENE-EXPRESSION ; BALANUS-IMPROVISUS ; OXIDATIVE STRESS ; CAPSAICIN ; PLANTS ; TECHNOLOGY ; SETTLEMENT ; BIOCIDES ; CHANNELS ; CELLS
WOS研究方向Environmental Sciences & Ecology ; Toxicology
语种英语
WOS记录号WOS:000316621700011
资助机构National Science and Technology Supporting Item [2011BAC02B04]; National High Technology Research and Development Program of China [2010AA065105]; Chinese Academy of Sciences and Local Governments [Y12B051011]; Yantai Science and Technology Bureau [2011063]
公开日期2013-08-14
源URL[http://ir.yic.ac.cn/handle/133337/6471]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing 100864, Shandong, Peoples R China
2.Liaoning Univ, Sch Chem, Shenyang 110036, Liaoning, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Jun,Yang, Cuiyun,Wang, Jianhua,et al. Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2013,32(4):802-809.
APA Zhou, Jun.,Yang, Cuiyun.,Wang, Jianhua.,Sun, Pengcheng.,Fan, Ping.,...&Xia, Chuanhai.(2013).Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,32(4),802-809.
MLA Zhou, Jun,et al."Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 32.4(2013):802-809.

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来源：烟台海岸带研究所

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