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Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons

文献类型：期刊论文

作者Liao, Chun-yang1,2; Cui, Lin1; Zhou, Qun-fang1; Duan, Shu-min3,4; Jiang, Gui-bin1
刊名ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
出版日期2009-05-01
卷号27期号:3页码:338-344
ISSN号1382-6689
关键词Perfluorooctane Sulfonate (Pfos) Neurotoxicity Potassium Channel Sodium Channel Glutamate-activated Current
通讯作者Jiang, GB, Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr, POB 2871, Beijing 100085, Peoples R China
产权排序Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr; Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev;Chinese Acad Sci, Inst Neurosci;Chinese Acad Sci, State Key Lab Neurobiol, Shanghai Inst Biol Sci
文献子类Article
英文摘要Concern on an emerging persistent contaminant, perfluorooctane sulfonate (PFOS), is increasingly growing. Although the fate, transport. distribution and bioaccumulation of PFOS have been documented, its toxicological effects especially neurotoxicity remain largely unknown. In this study, the effects of PFOS on ion channels including potassium and sodium channels and exogenous glutamate-activated current in cultured rat hippocampal neurons were examined, based on whole-cell patch-clamp recording. PFOS markedly increased two subtypes of potassium currents, including transient outward current and delayed rectifier current, at doses over 10 mu M. PFOS did not affect the amplitude of sodium current at all administrated doses (1, 10 or 100 mu M) but clearly shifted the activation current-voltage curve toward negatively potential. Further. PFOS significantly altered the glutamate-activated current at all doses. Taken together these findings indicated that PFOS disturbs the neuronal physiological processes, which revealed the damage of this pollutant to nerve system and will be helpful for further exploration to its underlying mechanism. (C) 2009 Published by Elsevier B.V.
学科主题Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology
URL标识查看原文
WOS关键词VENTRICULAR MYOCYTES ; PERFLUORINATED COMPOUNDS ; PERFLUOROALKYL ACIDS ; PFOA CONCENTRATIONS ; MASS-SPECTROMETRY ; NHANES 1999-2000 ; NATIONAL-HEALTH ; US POPULATION ; K+ CURRENT ; INHIBITION
WOS研究方向Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
语种英语
WOS记录号WOS:000265479000005
资助机构National Natural Science Foundation of China ; National Basic Research Program of China ; Chinese Academy of Sciences
公开日期2011-07-05
源URL[http://ir.yic.ac.cn/handle/133337/3529]  
专题烟台海岸带研究所_污染过程与控制实验室
作者单位1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev, Yantai 264003, Shandong, Peoples R China
3.Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China
4.Chinese Acad Sci, State Key Lab Neurobiol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Liao, Chun-yang,Cui, Lin,Zhou, Qun-fang,et al. Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(3):338-344.
APA Liao, Chun-yang,Cui, Lin,Zhou, Qun-fang,Duan, Shu-min,&Jiang, Gui-bin.(2009).Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(3),338-344.
MLA Liao, Chun-yang,et al."Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.3(2009):338-344.

入库方式： OAI收割

来源：烟台海岸带研究所

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