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Molecular fluorescent probes for monitoring pH changes in living cells

文献类型：期刊论文

作者Wang, Rui1; Yu, Chunwei1,2; Yu, Fabiao1; Chen, Lingxin1
刊名TRAC-TRENDS IN ANALYTICAL CHEMISTRY
出版日期2010-10-01
卷号29期号:9页码:1004-1013
关键词Fluorescence Microscopy Fluorescent Probe Intracellular Ph Living Cell Organic Synthesis Ph Detection Ph Indicator Ph Regulation Signal Transduction Small Molecular Probe
ISSN号0165-9936
产权排序[Wang, Rui; Yu, Chunwei; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yu, Chunwei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
通讯作者Chen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
文献子类Review
英文摘要The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.; The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题Chemistry, Analytical
URL标识查看原文
WOS关键词AQUEOUS-SOLUTIONS ; INTRACELLULAR PH ; HEPG2 CELLS ; SENSORS ; ACIDIFICATION ; DERIVATIVES ; DYES ; CA2+ ; EXCITATION ; INHIBITION
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000282542800014
资助机构Department of Science and Technology of Shandong Province of China [2008GG20005005]; National Natural Science Foundation of China [20975089]; Natural Science Foundation of Shandong Province of China [Y2007B38]; Chinese Academy of Sciences
公开日期2011-07-14
源URL[http://ir.yic.ac.cn/handle/133337/3720]  
专题烟台海岸带研究所_山东省海岸带环境工程技术研究中心
作者单位1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Rui,Yu, Chunwei,Yu, Fabiao,et al. Molecular fluorescent probes for monitoring pH changes in living cells[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2010,29(9):1004-1013.
APA Wang, Rui,Yu, Chunwei,Yu, Fabiao,&Chen, Lingxin.(2010).Molecular fluorescent probes for monitoring pH changes in living cells.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,29(9),1004-1013.
MLA Wang, Rui,et al."Molecular fluorescent probes for monitoring pH changes in living cells".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 29.9(2010):1004-1013.

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来源：烟台海岸带研究所

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