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Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)

文献类型：期刊论文

作者Zhou, Hailong1,2,3,4,5; Qu, Ying1,3,4; Wu, Huifeng1,3; Liao, Chunyang1,3; Zheng, Jiping2; Diao, Xiaoping2; Xue, Qinzhao1,3
刊名CHEMOSPHERE
出版日期2010
卷号78期号:2页码:193-205
关键词Ahr Pathway Non-synonymous Nucleotide Substitutions (d(n)) Synonymous Nucleotide Substitutions (d(s)) Persistent Organic Pollutants (Pops)
ISSN号0045-6535
产权排序[Zhou, Hailong; Qu, Ying; Wu, Huifeng; Liao, Chunyang; Xue, Qinzhao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China; [Zhou, Hailong; Zheng, Jiping; Diao, Xiaoping] Hainan Univ, Coll Agr, Dept Biotechnol, Haikou 570228, Peoples R China; [Zhou, Hailong; Qu, Ying; Wu, Huifeng; Liao, Chunyang; Xue, Qinzhao] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China; [Zhou, Hailong; Qu, Ying] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
通讯作者Xue, QZ, Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Shandong, Peoples R China
文献子类Review
英文摘要Phylogenetic analysis of AhR pathway genes and their evolutionary rate variations were studied on aquatic animals. The gene sequences for the proteins involved in this pathway were obtained from four major phylogenetic groups, including bivalvia, amphibian, teleostei and mammalia. These genes were distributed under four major steps of toxicology regulation: formation of cytosolic complex, translocation of AhR, heterodimerization of AhR and induction of CYP1A. The NJ, MP, and ML algorithm were used on protein coding DNA sequences to deduce the evolutionary relationship for the respective AhR pathway gene among different aquatic animals. The rate of non-synonymous nucleotide substitutions per non-synonymous site (d(N)) and synonymous nucleotide substitutions per synonymous site (d(S)) were calculated for different clade of the respective phylogenetic tree for each AhR pathway gene. The phylogenetic analysis suggests that evolutionary pattern of AhR pathway genes in aquatic animals is characterized mainly through gene duplication events or alterative splicing. The d(N) values indicate that all AhR pathway genes are well conserved in aquatic animals, except for CYP1A gene. Furthermore, compare with other aquatic animals, the d(N) value indicates that AhR pathway genes of fish are less conserved, and these genes likely go through an adaptive evolution within aquatic animals. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.; Phylogenetic analysis of AhR pathway genes and their evolutionary rate variations were studied on aquatic animals. The gene sequences for the proteins involved in this pathway were obtained from four major phylogenetic groups, including bivalvia, amphibian, teleostei and mammalia. These genes were distributed under four major steps of toxicology regulation: formation of cytosolic complex, translocation of AhR, heterodimerization of AhR and induction of CYP1A. The NJ, MP, and ML algorithm were used on protein coding DNA sequences to deduce the evolutionary relationship for the respective AhR pathway gene among different aquatic animals. The rate of non-synonymous nucleotide substitutions per non-synonymous site (d(N)) and synonymous nucleotide substitutions per synonymous site (d(S)) were calculated for different clade of the respective phylogenetic tree for each AhR pathway gene. The phylogenetic analysis suggests that evolutionary pattern of AhR pathway genes in aquatic animals is characterized mainly through gene duplication events or alterative splicing. The d(N) values indicate that all AhR pathway genes are well conserved in aquatic animals, except for CYP1A gene. Furthermore, compare with other aquatic animals, the d(N) value indicates that AhR pathway genes of fish are less conserved, and these genes likely go through an adaptive evolution within aquatic animals. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
学科主题Environmental Sciences
URL标识查看原文
WOS关键词NUCLEAR TRANSLOCATOR ARNT ; KILLIFISH FUNDULUS-HETEROCLITUS ; ZEBRAFISH DANIO-RERIO ; FROG XENOPUS-LAEVIS ; SALMON SALMO-SALAR ; HEAT-SHOCK-PROTEIN ; DNA-BINDING ; DIOXIN RECEPTOR ; LIGAND-BINDING ; FUNCTIONAL-CHARACTERIZATION
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000272888200017
资助机构Chinese Academy of Sciences [KZCX2-YW-Q07-05]; Yantai Research and Development Program [2007323]; National Natural Science Foundation of China [20907039]; Natural Science Foundation of Hainan Province [309010]
公开日期2011-07-14
源URL[http://ir.yic.ac.cn/handle/133337/3798]  
专题烟台海岸带研究所_污染过程与控制实验室
烟台海岸带研究所_中科院烟台海岸带研究所知识产出
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
2.Hainan Univ, Coll Agr, Dept Biotechnol, Haikou 570228, Peoples R China
3.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Hailong,Qu, Ying,Wu, Huifeng,et al. Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)[J]. CHEMOSPHERE,2010,78(2):193-205.
APA Zhou, Hailong.,Qu, Ying.,Wu, Huifeng.,Liao, Chunyang.,Zheng, Jiping.,...&Xue, Qinzhao.(2010).Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs).CHEMOSPHERE,78(2),193-205.
MLA Zhou, Hailong,et al."Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)".CHEMOSPHERE 78.2(2010):193-205.

入库方式： OAI收割

来源：烟台海岸带研究所

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