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Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

文献类型：期刊论文

作者Lou, Tingting1,2,5; Wang, Yunqing1,2; Li, Jinhua1,2; Peng, Hailong3,4; Xiong, Hua3; Chen, Lingxin1,2
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
出版日期2011-07-01
卷号401期号:1页码:333-338
关键词Melamine Surface-enhanced Raman Scattering Gold Nanoparticle 4-mercaptopyridine
ISSN号1618-2642
产权排序[Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China; [Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Peng, Hailong; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China; [Peng, Hailong] Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China; [Lou, Tingting] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
通讯作者Chen, LX, CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China.lxchen@yic.ac.cn
文献子类Article
英文摘要A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices. .; A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices.
学科主题Biochemical Research Methods ; Chemistry, Analytical
WOS关键词MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; SILVER ELECTRODE ; INFANT FORMULA ; CYANURIC ACID ; SPECTROSCOPY ; MILK ; NANOCRYSTALS ; MOLECULES ; IDENTIFICATION
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000292156900031
资助机构National Natural Science Foundation China [20807035, 50728806]; Chinese Academy of Sciences [KZCX2-YW-Q07-04]; Agency for Science, technology and Research (A*Star) of Singapore [R-288-000-066-305, 092 101 0059]
公开日期2011-07-22
源URL[http://ir.yic.ac.cn/handle/133337/4852]  
专题烟台海岸带研究所_山东省海岸带环境工程技术研究中心
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位1.CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
4.Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China
5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Lou, Tingting,Wang, Yunqing,Li, Jinhua,et al. Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2011,401(1):333-338.
APA Lou, Tingting,Wang, Yunqing,Li, Jinhua,Peng, Hailong,Xiong, Hua,&Chen, Lingxin.(2011).Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,401(1),333-338.
MLA Lou, Tingting,et al."Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 401.1(2011):333-338.

入库方式： OAI收割

来源：烟台海岸带研究所

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