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Assessment of Clam Ruditapes philippinarum as Heavy Metal Bioindicators Using NMR-Based Metabolomics

文献类型：期刊论文

作者Liu, Xiaoli1,2; Zhang, Linbao1,2; You, Liping1,2; Yu, Junbao1; Cong, Ming1; Wang, Qing1; Li, Fei1; Li, Lianzhen1; Zhao, Jianmin1; Li, Chenghua1
刊名CLEAN-SOIL AIR WATER
出版日期2011-08-01
卷号39期号:8页码:759-766
关键词Bioindicator Manila Clam Mercury Metabolomics Nmr
ISSN号1863-0650
产权排序[Liu, XL; Zhang, LB; You, LP; Yu, JB; Cong, M; Wang, Q; Li, F; Li, LZ; Zhao, JM; Li, CH; Wu, HF] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,CAS, Yantai 264003, Peoples R China; [Liu, XL; Zhang, LB; You, LP] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
通讯作者Wu, HF, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,CAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
文献子类Article
英文摘要There are mainly distributed three pedigrees (White, Liangdao Red, and Zebra) of Manila clam Ruditapes philippinarum in Yantai population along the Bohai marine and coast. However, the biological differences to environmental stressors have been ignored in toxicology studies, which could lead to the distortion of biological interpretations of toxicological effects induced by environmental contaminants. In this study, we applied a system biology approach, metabolomics to compare the metabolic profiles in digestive gland from three pedigrees of clam and characterize and compare the metabolic responses induced by mercury in clam digestive gland tissues to determine a sensitive pedigree of clam as a preferable bioindicator for metal pollution monitoring and toxicology research. The most abundant metabolites, respectively, included branched-chain amino acids, alanine, and arginine in White samples, glutamate, dimethylglycine, and glycine in Zebra clams and acetylcholine, betaine, glucose, and glycogen in Liangdao Red clams. After 48 h exposure of 20 mu g L(-1) Hg(2+), the metabolic profiles from the three pedigrees of clams showed differentially significant changes in alanine, glutamate, succinate, taurine, hypotaurine, glycine, arginine, glucose, etc. Our findings indicate the toxicological effects of mercury exposure in Manila clams including the neurotoxicity, disturbances in energetic metabolisms and osmoregulation in the digestive glands and suggest that Liangdao Red pedigree of clam could be a preferable bioindicator for the metal pollution monitoring based on the more sensitive classes of metabolic changes from digestive glands compared with other two (White and Zebra) pedigrees of clams.; There are mainly distributed three pedigrees (White, Liangdao Red, and Zebra) of Manila clam Ruditapes philippinarum in Yantai population along the Bohai marine and coast. However, the biological differences to environmental stressors have been ignored in toxicology studies, which could lead to the distortion of biological interpretations of toxicological effects induced by environmental contaminants. In this study, we applied a system biology approach, metabolomics to compare the metabolic profiles in digestive gland from three pedigrees of clam and characterize and compare the metabolic responses induced by mercury in clam digestive gland tissues to determine a sensitive pedigree of clam as a preferable bioindicator for metal pollution monitoring and toxicology research. The most abundant metabolites, respectively, included branched-chain amino acids, alanine, and arginine in White samples, glutamate, dimethylglycine, and glycine in Zebra clams and acetylcholine, betaine, glucose, and glycogen in Liangdao Red clams. After 48 h exposure of 20 mu g L-1 Hg2+, the metabolic profiles from the three pedigrees of clams showed differentially significant changes in alanine, glutamate, succinate, taurine, hypotaurine, glycine, arginine, glucose, etc. Our findings indicate the toxicological effects of mercury exposure in Manila clams including the neurotoxicity, disturbances in energetic metabolisms and osmoregulation in the digestive glands and suggest that Liangdao Red pedigree of clam could be a preferable bioindicator for the metal pollution monitoring based on the more sensitive classes of metabolic changes from digestive glands compared with other two (White and Zebra) pedigrees of clams.
学科主题Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Water Resources
WOS关键词LAGOON-OF-VENICE ; TAPES-PHILIPPINARUM ; MYTILUS-GALLOPROVINCIALIS ; H-1-NMR METABOLOMICS ; PATTERN-RECOGNITION ; MANILA CLAM ; SPECTROSCOPY ; METABONOMICS ; EXTRACTION ; POLLUTION
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Water Resources
语种英语
WOS记录号WOS:000294720700007
资助机构Chinese Academy of Sciences; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA
公开日期2011-11-11
源URL[http://ir.yic.ac.cn/handle/133337/5118]  
专题烟台海岸带研究所_近岸生态与环境实验室
烟台海岸带研究所_滨海湿地实验室
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,CAS, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xiaoli,Zhang, Linbao,You, Liping,et al. Assessment of Clam Ruditapes philippinarum as Heavy Metal Bioindicators Using NMR-Based Metabolomics[J]. CLEAN-SOIL AIR WATER,2011,39(8):759-766.
APA Liu, Xiaoli.,Zhang, Linbao.,You, Liping.,Yu, Junbao.,Cong, Ming.,...&Wu, Huifeng.(2011).Assessment of Clam Ruditapes philippinarum as Heavy Metal Bioindicators Using NMR-Based Metabolomics.CLEAN-SOIL AIR WATER,39(8),759-766.
MLA Liu, Xiaoli,et al."Assessment of Clam Ruditapes philippinarum as Heavy Metal Bioindicators Using NMR-Based Metabolomics".CLEAN-SOIL AIR WATER 39.8(2011):759-766.

入库方式： OAI收割

来源：烟台海岸带研究所

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