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Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics

文献类型：期刊论文

作者Zhang, Linbao1,2,3; Liu, Xiaoli1,2,3; You, Liping1,2,3; Zhou, Di1,2,3; Wu, Huifeng1,2; Li, Lianzhen1,2; Zhao, Jianmin1,2; Feng, Jianghua4; Yu, Junbao1,2
刊名MARINE ENVIRONMENTAL RESEARCH
出版日期2011-07-01
卷号72期号:1-2页码:33-39
关键词Copper Heavy Metal Toxicity Metabolites Biomarkers Manila Clam Bioindicator Metabolomics
ISSN号0141-1136
产权排序[Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wu, Huifeng; Li, Lianzhen; Zhao, Jianmin; Yu, Junbao] CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wu, Huifeng; Li, Lianzhen; Zhao, Jianmin; Yu, Junbao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [Feng, Jianghua] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Fujian Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China
通讯作者Wu, HF (reprint author), CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
文献子类Article
英文摘要Copper is an important heavy metal contaminant with high ecological risk in the Bohai Sea. In this study, the metabolic responses in the bioindicator, Manila clam (Ruditapes philippinarum), to the environmentally relevant copper exposures were characterized using NMR-based metabolomics. The significant metabolic changes corresponding to copper exposures were related to osmolytes, intermediates of the Krebs cycle and amino acids, such as the increase in homarine, branched chain amino acids and decrease in succinate, alanine and dimethylamine in the copper-exposed clam gills during 96 h exposure period. Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period. These results demonstrate that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. (C) 2011 Elsevier Ltd. All rights reserved.; Copper is an important heavy metal contaminant with high ecological risk in the Bohai Sea. In this study, the metabolic responses in the bioindicator, Manila clam (Ruditapes philippinarum), to the environmentally relevant copper exposures were characterized using NMR-based metabolomics. The significant metabolic changes corresponding to copper exposures were related to osmolytes, intermediates of the Krebs cycle and amino acids, such as the increase in homarine, branched chain amino acids and decrease in succinate, alanine and dimethylamine in the copper-exposed clam gills during 96 h exposure period. Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period. These results demonstrate that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
URL标识查看原文
WOS关键词MAGNETIC-RESONANCE-SPECTROSCOPY ; MUSSEL MYTILUS-EDULIS ; PATTERN-RECOGNITION ; H-1-NMR METABOLOMICS ; TIDAL FLATS ; LIVER ; EXTRACTION ; POLLUTION ; DISEASE ; GALLOPROVINCIALIS
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
语种英语
WOS记录号WOS:000295349300005
资助机构Chinese Academy of Sciences[KZCX2-YW-Q07-04]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA
公开日期2012-03-06
源URL[http://ir.yic.ac.cn/handle/133337/5377]  
专题烟台海岸带研究所_污染过程与控制实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
烟台海岸带研究所_滨海湿地实验室
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Fujian Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics[J]. MARINE ENVIRONMENTAL RESEARCH,2011,72(1-2):33-39.
APA Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Wu, Huifeng.,...&Yu, Junbao.(2011).Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics.MARINE ENVIRONMENTAL RESEARCH,72(1-2),33-39.
MLA Zhang, Linbao,et al."Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics".MARINE ENVIRONMENTAL RESEARCH 72.1-2(2011):33-39.

入库方式： OAI收割

来源：烟台海岸带研究所

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