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  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 中科院海岸带环境过程与生态修复重点实验室
A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities

文献类型：期刊论文

作者Wu, Huifeng1,2; Zhang, Xingyan1,2,3; Wang, Qing1,2; Li, Lianzhen1,2; Ji, Chenglong1,2,3; Liu, Xiaoli1,2,3; Zhao, Jianmin1,2; Yin, Xiuli1,2
刊名ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
出版日期2013-04-01
卷号90页码:1-6
关键词Ruditapes Philippinarum Arsenic Toxicological Effects Nmr Metabolomics
ISSN号0147-6513
产权排序[Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli] YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China; [Zhang, Xingyan; Ji, Chenglong; Liu, Xiaoli] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
通讯作者Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
文献子类Article
英文摘要Arsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved.; Arsenic is an important contaminant in the Bohai marine ecosystem due to the anthropogenic activities. In this work, we investigated the toxicological effects of arsenic in Ruditapes philippinarum under different seawater salinities using NMR-based metabolomics. Under normal salinity (31.1 ppt), arsenic decreased the levels of amino acids (glutamate, beta-alanine, etc.), and increased the levels of betaine and fumarate. The metabolic biomarkers including decreased threonine, histidine, ATP and fumarate were found in the muscles of arsenic-treated clams under medium salinity (23.3 ppt). However, only elevated ATP and depleted succinate were detected in the arsenic-exposed clam samples under low salinity (15.6 ppt). These differential metabolic biomarkers indicated that arsenic could induce osmotic stress and disturbance in energy metabolism in clam under normal and medium salinities. However, arsenic caused only disturbance in energy metabolism in clam under low salinity. Overall, our results demonstrated that seawater salinity could influence the toxicological effects of arsenic. (C) 2012 Elsevier Inc. All rights reserved.
学科主题Environmental Sciences ; Toxicology
URL标识查看原文
WOS关键词NMR-BASED METABOLOMICS ; MAGNETIC-RESONANCE-SPECTROSCOPY ; H-1-NMR METABOLOMICS ; PATTERN-RECOGNITION ; TAPES-PHILIPPINARUM ; OXIDATIVE STRESS ; MANILA CLAMS ; RESPONSES ; METABONOMICS ; TRANSFORMATION
WOS研究方向Environmental Sciences & Ecology ; Toxicology
语种英语
WOS记录号WOS:000315840000001
资助机构NSFC [41106102]; SDSFC [ZR2009CZ008]; The 100 Talents Program of the Chinese Academy of Sciences
公开日期2013-08-15
源URL[http://ir.yic.ac.cn/handle/133337/6591]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Shandong, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Huifeng,Zhang, Xingyan,Wang, Qing,et al. A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2013,90:1-6.
APA Wu, Huifeng.,Zhang, Xingyan.,Wang, Qing.,Li, Lianzhen.,Ji, Chenglong.,...&Yin, Xiuli.(2013).A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,90,1-6.
MLA Wu, Huifeng,et al."A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 90(2013):1-6.

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来源：烟台海岸带研究所

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