中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 中科院海岸带环境过程与生态修复重点实验室
A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside

文献类型：期刊论文

作者Peng, Hailong1,2; Dong, Ruichen1; Wang, Shenqi1; Zhang, Zhong3; Luo, Mei1,2; Bai, Chunqing1; Zhao, Qiang1; Li, Jinhua3; Chen, Lingxin3; Xiong, Hua1
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2013-03-25
卷号446期号:1-2页码:153-159
关键词Mesoporous Silica Nanoparticles Poly(Acrylic Acid) Ph-responsive Controlled Release Salidroside
ISSN号0378-5173
产权排序[Peng, Hailong; Dong, Ruichen; Wang, Shenqi; Luo, Mei; Bai, Chunqing; Zhao, Qiang; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China; [Peng, Hailong; Luo, Mei] Nanchang Univ, Dept Chem Engn, Nanchang 330031, Peoples R China; [Zhang, Zhong; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
通讯作者Xiong, H (reprint author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China. huaxiong100@yahoo.com.cn
文献子类Article
英文摘要A novel pH-responsive nano-carrier MSNs-PAA, possessing mesoporous silica nanoparticles (MSNs) cores and poly(acrylic acid) (PAA) shell-layers, was developed for controlled release of salidroside. The vinyl double bonds modified MSNs were synthesized by using cetyltrimethylammonium bromide (CTAB) as templates, tetraethyl orthosilicate (TEOS) as silicon source, and 3-(trimethoxylsilyl) propyl methacrylate (MPS) as surface modification functionalities. The pH-responsive layers of PAA were grafted onto the vinyl double bonds of the MSNs via precipitation polymerization, producing the MSNs-PAA with a hollow cubic core and mesoporous shell with penetrating pore channels. The characteristic results also showed that PAA was successfully grafted onto the surface of the MSNs. The MSNs-PAA was investigated as carriers for loading and regulating the release of salidroside in different pH solutions for the first time. The results demonstrated that the PAA layers on the surface of MSNs-PAA exhibited opened and closed states at different pH values, and thus could regulate the uptake and release of salidroside. The application of such pH-responsive nano-carrier might offer a potential platform for controlled delivery and increasing the bioavailability of drugs. (C) 2013 Elsevier B. V. All rights reserved.; A novel pH-responsive nano-carrier MSNs-PAA, possessing mesoporous silica nanoparticles (MSNs) cores and poly(acrylic acid) (PAA) shell-layers, was developed for controlled release of salidroside. The vinyl double bonds modified MSNs were synthesized by using cetyltrimethylammonium bromide (CTAB) as templates, tetraethyl orthosilicate (TEOS) as silicon source, and 3-(trimethoxylsilyl) propyl methacrylate (MPS) as surface modification functionalities. The pH-responsive layers of PAA were grafted onto the vinyl double bonds of the MSNs via precipitation polymerization, producing the MSNs-PAA with a hollow cubic core and mesoporous shell with penetrating pore channels. The characteristic results also showed that PAA was successfully grafted onto the surface of the MSNs. The MSNs-PAA was investigated as carriers for loading and regulating the release of salidroside in different pH solutions for the first time. The results demonstrated that the PAA layers on the surface of MSNs-PAA exhibited opened and closed states at different pH values, and thus could regulate the uptake and release of salidroside. The application of such pH-responsive nano-carrier might offer a potential platform for controlled delivery and increasing the bioavailability of drugs. (C) 2013 Elsevier B. V. All rights reserved.
学科主题Pharmacology & Pharmacy
URL标识查看原文
WOS关键词MOLECULARLY IMPRINTED POLYMERS ; SOLID-PHASE EXTRACTION ; DRUG-DELIVERY ; RHODIOLA-ROSEA ; IN-VITRO ; SYSTEM ; CELLS ; MICROSPHERES ; PERFORMANCE ; APOPTOSIS
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000316736500019
资助机构National Natural Science Foundation of China [21201098, 31160317, 21275158, 21105117]; Specialized Research Fund for the Doctoral Program of Higher Education [20113601110004]; 100 Talents Program of the Chinese Academy of Sciences
公开日期2013-08-15
源URL[http://ir.yic.ac.cn/handle/133337/6593]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
2.Nanchang Univ, Dept Chem Engn, Nanchang 330031, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Peng, Hailong,Dong, Ruichen,Wang, Shenqi,et al. A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,446(1-2):153-159.
APA Peng, Hailong.,Dong, Ruichen.,Wang, Shenqi.,Zhang, Zhong.,Luo, Mei.,...&Xiong, Hua.(2013).A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside.INTERNATIONAL JOURNAL OF PHARMACEUTICS,446(1-2),153-159.
MLA Peng, Hailong,et al."A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: Fabrication, characterization and properties for controlled release of salidroside".INTERNATIONAL JOURNAL OF PHARMACEUTICS 446.1-2(2013):153-159.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。